Ir-catalyzed proximal and distal C–H borylation of arenes

2021 ◽  
Author(s):  
Chabush Haldar ◽  
Md Emdadul Hoque ◽  
Jagriti Chaturvedi ◽  
Mirja Md Mahamudul Hassan ◽  
Buddhadeb Chattopadhyay
Keyword(s):  
Transition Metal ◽  
Bond Activation ◽  
Metal Catalysts ◽  
Transition Metal Catalysts ◽  
The Past ◽  
Functionalization Reaction

Over the past two decades, the C–H bond activation and functionalization reaction has been known as a prevailing method for the construction of carbon–carbon and carbon–heteroatom bonds using various transition metal catalysts.

Boron Lewis Pair Mediated C-H Activation and Borylation

Synthesis ◽  
2021 ◽  
Author(s):  
Frédéric-Georges Fontaine ◽  
Vincent Desrosiers
Keyword(s):  
Transition Metal ◽  
Bond Activation ◽  
Metal Catalysts ◽  
Transition Metal Catalysts ◽  
Frustrated Lewis Pairs ◽  
The Past ◽  
The Subject ◽  
Lewis Pairs

In the past years, the chemistry of Frustrated Lewis pairs enabled a plethora of transformations that would otherwise only be possible using transition metal catalysts. Of particular interest are the C-H bond activation and borylation reactions, which is the subject of this review. The FLP borylation chemistry is compared with the early borylation methodologies using strongly electrophilic borenium ions. We present the mechanism of the C-H borylation using inter- and intramolecular Lewis pairs, along with some applications of these transformations.

Soluble polymer-supported organocatalysts

2012 ◽  
Vol 85 (3) ◽  
pp. 493-509 ◽  
Author(s):  
Yun-Chin Yang ◽  
David E. Bergbreiter
Keyword(s):  
Transition Metal ◽  
Organic Synthesis ◽  
Metal Catalysts ◽  
Transition Metal Catalysts ◽  
Soluble Polymer ◽  
Soluble Polymers ◽  
The Past ◽  
Polymer Supports ◽  
Polymer Supported ◽  
Simple Product

Organocatalysts have been extensively studied for the past few decades as alternatives to transition-metal catalysts. Immobilizing organocatalysts on polymer supports allows easy recovery and simple product purification after a reaction. Select examples of recent reports that describe the potential advantages of using soluble polymers to prepare soluble polymer-supported organocatalysts useful in organic synthesis are reviewed.

Step-Economical C–H Activation Reactions Directed by In Situ Amidation

Synthesis ◽  
2020 ◽  
Vol 52 (21) ◽  
pp. 3211-3218
Author(s):  
Yunyun Liu ◽  
Baoli Zhao
Keyword(s):  
Transition Metal ◽  
Bond Activation ◽  
Short Review ◽  
Metal Catalysts ◽  
Transition Metal Catalysts ◽  
Directing Group ◽  
Crude Material

Owing to the inherent ability of amides to chelate transition-metal catalysts, amide-directed C–H activation reactions constitute a major tactic in directed C–H activation reactions. While the conventional procedures for these reactions usually involve prior preparation and purification of amide substrates before the C–H activation, the step economy is actually undermined by the operation of installing the directing group (DG) and related substrate purification. In this context, directed C–H activation via in situ amidation of the crude material provides a new protocol that can significantly enhance the step economy of amide-directed C–H activation. In this short review, the advances in C–H bond activation reactions mediated or initiated by in situ amidation are summarized and analyzed.1 Introduction2 In Situ Amidation in Aryl C–H Bond Activation3 In Situ Amidation in Alkyl C–H Bond Activation4 Annulation Reactions via Amidation-Mediated C–H Activation5 Remote C–H Activation Mediated by Amidation6 Conclusion

A Review on Sulfur-Directed C−H Bond Activation

2020 ◽  
Vol 17 ◽  
Author(s):  
Xuchong Tang ◽  
Yingwei Zhao
Keyword(s):  
Transition Metal ◽  
Electron Donor ◽  
Bond Activation ◽  
Bond Formation ◽  
Metal Catalysts ◽  
Transition Metal Catalysts ◽  
Directing Group ◽  
Metal Catalyzed ◽  
Sulfur Containing

: Transition-metal-catalyzed C−H bond activation employing a directing group is becoming a powerful tool to access C−C or C−hetero bond formation. Oxygen and nitrogen atoms are commonly applied as the electron donor for these directing groups. In contrast, there are only few studies on sulfur-containing groups, probably due to their toxicity to transition-metal catalysts. Nowadays a large amount of C−H activation reactions directed by sulfur-containing auxiliary groups have been successfully achieved. Because these groups can be facilely removed or modified in situ or in further steps, they are of great value in creative synthetic strategies. This paper reviews recent advances in the studies using thioether, thiol/thiophenol/disulfide, sulfoxide, and thiocarbonyl as directing groups for intermolecular C−H functionalizations as well as intramolecular oxidative annulations.

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