Ir-catalyzed proximal and distal C–H borylation of arenes

Over the past two decades, the C–H bond activation and functionalization reaction has been known as a prevailing method for the construction of carbon–carbon and carbon–heteroatom bonds using various transition metal catalysts.

N-Heterocyclic carbene catalyzed asymmetric [3 + 3] cycloaddtion of β,β-disubstituted, α,β-unsaturated carboxylic esters with 3-aminobenzofurans

An NHC-catalyzed β-carbon functionalization reaction to afford enantioenriched benzofuran fused δ-lactams bearing an all-carbon quaternary stereocenter is documented.

Application of Readily Available Metals for C-H Activation

Catalytic C-H activation is a powerful method for organic synthesis. In recent years, scientists have made great progress by developing transitional metals for catalyzing CH functionalization reaction. In this review, we summarized and highlighted recent progress in C-H activation with copper, cobalt, iron, manganese, and nickel as catalysts.

4’-Methyl-2’-(quinolin-8-ylcarbamoyl)-biphenyl-4-carboxylic Acid Ethyl Ester

In this short note communication, we report the synthesis of a novel amide 4’-methyl-2’-(quinolin-8-ylcarbamoyl)-biphenyl-4-carboxylic acid ethyl ester by the Ru-catalyzed C(sp2)-H bond arylation reaction. The catalytic C-H bond functionalization reaction was employed, amongst other reaction reagents and conditions, [RuCl2(p-cymene)]2 as a precatalyst and (p-tol)3P as a ligand. The arylation product was characterized by various spectroscopic methods (1H NMR, 13C NMR, IR, GC-MS, and IR spectroscopy), and its composition was confirmed by elemental analysis.

C-H Functionalization Reactions of Unprotected N-Heterocycles by Gold Catalyzed Carbene Transfer

<p>The C-H functionalization reaction of N-heterocycles with unprotected N-H group is one of the most step-economic strategies to introduce functional groups without the need of installation and removal of protecting groups. Despite recent significant advances in C-H functionalization chemistry, this strategy remains unsatisfactorily developed. In this report, we disclose a simple and straightforward protocol to allow for the selective C-H functionalization of unprotected double benzannellated N-heterocycles via gold catalyzed carbene transfer reactions (29 examples, up to 86% yield). The scope of the reaction can also be expanded to the corresponding protected heterocycles (37 examples, up to 98% yield), further demonstrating the generality of this method. Mechanistic studies by DFT calculations underpin the importance of the gold catalyst and reveal that the selectivity of this reaction is driven by trace amounts of water present in the reaction mixture.</p>