Structural evolution of toll-like receptor 7/8 agonists from imidazoquinolines to imidazoles

2021 ◽  
Author(s):  
Deepender Kaushik ◽  
Arshpreet Kaur ◽  
Nikolai Petrovsky ◽  
Deepak B. Salunke
Keyword(s):  
Structural Evolution ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Vaccine Adjuvant ◽  
Toll Like Receptor ◽  
Detailed Structure ◽  
Structure Activity

TLR7/8 agonists are emerging as promising vaccine adjuvant candidates. An evolution of imidazole based TLR7/8 agonist from imidazoquinoline based scaffold is delineated along with the elaboration of detailed structure activity relationship (SAR) in each chemotype.

scholarly journals Structure-Activity Relationship of Synthetic Toll-like Receptor 4 Agonists

2003 ◽  
Vol 279 (6) ◽  
pp. 4440-4449 ◽  
Author(s):  
Axel G. Stöver ◽  
Jean Da Silva Correia ◽  
Jay T. Evans ◽  
Christopher W. Cluff ◽  
Mark W. Elliott ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Structure Activity ◽  
Relationship Of

Structure–Activity Relationship Studies on the Immune Stimulatory Effects of Base-Modified CpG Toll-Like Receptor 9 Agonists

ChemMedChem ◽  
2006 ◽  
Vol 1 (9) ◽  
pp. 1007-1014 ◽  
Author(s):  
Marion Jurk ◽  
Andrea Kritzler ◽  
Harald Debelak ◽  
Jörg Vollmer ◽  
Arthur M. Krieg ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Toll Like Receptor ◽  
Structure Activity

scholarly journals Structure–Activity Relationship in Monosaccharide-Based Toll-Like Receptor 4 (TLR4) Antagonists

2018 ◽  
Vol 61 (7) ◽  
pp. 2895-2909 ◽  
Author(s):  
Fabio A. Facchini ◽  
Lenny Zaffaroni ◽  
Alberto Minotti ◽  
Silvia Rapisarda ◽  
Valentina Calabrese ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Structure Activity

scholarly journals Structure–Activity Relationship Studies of Pyrimido[5,4-b]indoles as Selective Toll-Like Receptor 4 Ligands

2017 ◽  
Vol 60 (22) ◽  
pp. 9142-9161 ◽  
Author(s):  
Michael Chan ◽  
Yuhei Kakitsubata ◽  
Tomoko Hayashi ◽  
Alast Ahmadi ◽  
Shiyin Yao ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Structure Activity

Toll-like Receptor 7 Selective Synthetic Oligoribonucleotide Agonists: Synthesis and Structure−Activity Relationship Studies

2009 ◽  
Vol 52 (21) ◽  
pp. 6871-6879 ◽  
Author(s):  
Tao Lan ◽  
Meiru Dai ◽  
Daqing Wang ◽  
Fu-Gang Zhu ◽  
Ekambar R. Kandimalla ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Toll Like Receptor ◽  
Structure Activity

Structure–activity relationship of lipopeptide Group A streptococcus (GAS) vaccine candidates on toll-like receptor 2

Vaccine ◽  
2010 ◽  
Vol 28 (10) ◽  
pp. 2243-2248 ◽  
Author(s):  
Mehfuz Zaman ◽  
Abu-Baker M. Abdel-Aal ◽  
Karen S.M. Phillipps ◽  
Yoshio Fujita ◽  
M.F. Good ◽  
...  
Keyword(s):  
Group A Streptococcus ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Toll Like Receptor ◽  
Vaccine Candidates ◽  
Structure Activity ◽  
Group A ◽  
Toll Like Receptor 2 ◽  
Relationship Of

Detailed structure–activity relationship of indolecarboxamides as H4 receptor ligands

2012 ◽  
Vol 54 ◽  
pp. 660-668 ◽  
Author(s):  
Harald Engelhardt ◽  
Iwan J.P. de Esch ◽  
Daniel Kuhn ◽  
Rogier A. Smits ◽  
Obbe P. Zuiderveld ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Receptor Ligands ◽  
Detailed Structure ◽  
Structure Activity ◽  
H4 Receptor ◽  
Relationship Of
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