TLR2 Agonistic Small Molecules: Detailed Structure–Activity Relationship, Applications, and Future Prospects

2020 ◽  
Author(s):  
Arshpreet Kaur ◽  
Deepender Kaushik ◽  
Sakshi Piplani ◽  
Surinder K. Mehta ◽  
Nikolai Petrovsky ◽  
...  
Keyword(s):  
Small Molecules ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Future Prospects ◽  
Detailed Structure ◽  
Structure Activity

Structural evolution of toll-like receptor 7/8 agonists from imidazoquinolines to imidazoles

2021 ◽  
Author(s):  
Deepender Kaushik ◽  
Arshpreet Kaur ◽  
Nikolai Petrovsky ◽  
Deepak B. Salunke
Keyword(s):  
Structural Evolution ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Vaccine Adjuvant ◽  
Toll Like Receptor ◽  
Detailed Structure ◽  
Structure Activity

TLR7/8 agonists are emerging as promising vaccine adjuvant candidates. An evolution of imidazole based TLR7/8 agonist from imidazoquinoline based scaffold is delineated along with the elaboration of detailed structure activity relationship (SAR) in each chemotype.

Detailed structure–activity relationship of indolecarboxamides as H4 receptor ligands

2012 ◽  
Vol 54 ◽  
pp. 660-668 ◽  
Author(s):  
Harald Engelhardt ◽  
Iwan J.P. de Esch ◽  
Daniel Kuhn ◽  
Rogier A. Smits ◽  
Obbe P. Zuiderveld ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Receptor Ligands ◽  
Detailed Structure ◽  
Structure Activity ◽  
H4 Receptor ◽  
Relationship Of

Structure-activity relationship of (-) mammea A/BB derivatives against Leishmania amazonensis

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
MA Brenzan ◽  
CV Nakamura ◽  
BPD Filho ◽  
T Ueda-Nakamura ◽  
MCM Young ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Leishmania Amazonensis ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of
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