Synthesis of dibenzocyclohepta[1,2-a]naphthalene derivatives from phenylacetaldehyde and alkynyl benzyl alcohols via sequential electrophilic addition and double Friedel–Crafts reactions

2021 ◽  
Vol 19 (11) ◽  
pp. 2430-2435
Author(s):  
Archana K. Sahu ◽  
Ramanjaneyulu Unnava ◽  
Bipin K. Behera ◽  
Anil K. Saikia
Keyword(s):  
Lewis Acid ◽  
Electrophilic Addition ◽  
Regioselective Synthesis ◽  
Naphthalene Derivatives ◽  
Benzyl Alcohols

A simple methodology for the regioselective synthesis of substituted dibenzocyclohepta[1,2-a]naphthalenes from phenylacetaldehydes and ortho-alkynyl benzyl alcohols in the presence of a Lewis acid has been developed.

Regioselective synthesis of functionalized dihydroisoquinolines from o-alkynylarylaldimines via the Reformatsky reaction

2016 ◽  
Vol 14 (41) ◽  
pp. 9896-9906 ◽  
Author(s):  
Tohasib Yusub Chaudhari ◽  
Urvashi Urvashi ◽  
Sandeep K. Ginotra ◽  
Pooja Yadav ◽  
Gulshan Kumar ◽  
...  
Keyword(s):  
Lewis Acid ◽  
Regioselective Synthesis ◽  
Reformatsky Reaction ◽  
Novel Approach ◽  
The Reformatsky Reaction

A novel approach for the synthesis of functionalized 1,2-dihydroisoquinolines from o-alkynylarylaldimines via the Reformatsky reaction without the aid of an external Lewis acid has been described.

Lewis Acid Activated Chiral Leaving Group: Enantioselective Electrophilic Addition to Prochiral Olefins.

ChemInform ◽  
2003 ◽  
Vol 34 (3) ◽  
Author(s):  
Hiroko Nakamura ◽  
Kazuaki Ishihara ◽  
Hisashi Yamamoto
Keyword(s):  
Lewis Acid ◽  
Electrophilic Addition ◽  
Leaving Group

An insight into the Lewis acid-catalyzed intramolecular aminocyanation and oxycyanation of alkenes: a concerted or stepwise mechanism

2015 ◽  
Vol 51 (84) ◽  
pp. 15450-15453 ◽  
Author(s):  
Jiyang Zhao ◽  
Guoqiang Wang ◽  
Shuhua Li
Keyword(s):  
Lewis Acid ◽  
Electrophilic Addition ◽  
Stepwise Mechanism ◽  
Acid Catalyzed ◽  
Insight Into

The Lewis-acid promoted intramolecular addition of X–CN (X = N, O) bonds to alkenes represents a novel type of electrophilic addition to alkenes.

ChemInform Abstract: Lewis Acid Facilitated Regioselective Synthesis of τ-Histidinoalanine.

ChemInform ◽  
2014 ◽  
Vol 45 (47) ◽  
pp. no-no
Author(s):  
Ju Wu ◽  
Bing Ma ◽  
Yuehui Wang ◽  
Yue Zhang ◽  
Shenghu Yan ◽  
...  
Keyword(s):  
Lewis Acid ◽  
Regioselective Synthesis

ChemInform Abstract: Lewis Acid Induced Highly Regioselective Synthesis of a New Class of Substituted Isoxazolidines.

ChemInform ◽  
2009 ◽  
Vol 40 (8) ◽  
Author(s):  
Fides Benfatti ◽  
Giuliana Cardillo ◽  
Luca Gentilucci ◽  
Elisa Mosconi ◽  
Alessandra Tolomelli
Keyword(s):  
Lewis Acid ◽  
Regioselective Synthesis ◽  
New Class

In situ activation of benzyl alcohols with XtalFluor-E: formation of 1,1-diarylmethanes and 1,1,1-triarylmethanes through Friedel–Crafts benzylation

2015 ◽  
Vol 13 (8) ◽  
pp. 2243-2246 ◽  
Author(s):  
Justine Desroches ◽  
Pier Alexandre Champagne ◽  
Yasmine Benhassine ◽  
Jean-François Paquin
Keyword(s):  
Transition Metal ◽  
Lewis Acid ◽  
Benzyl Alcohols ◽  
Mild Conditions ◽  
In Situ Activation ◽  
Wide Range ◽  
Strong Lewis Acid

The Friedel–Crafts benzylation of arenes using benzyl alcohols activated in situ with XtalFluor-E is described. A wide range of 1,1-diarylmethanes and 1,1,1-triarylmethanes were prepared under simple and mild conditions, without the need for a transition metal or a strong Lewis acid.

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