Solid-phase synthesis of coralmycin A/epi-coralmycin A and desmethoxycoralmycin A

Author(s):  
Paige Hawkins ◽  
Dennis Y. Liu ◽  
Roger Gareth Linington ◽  
Richard James Payne

The total synthesis of the natural product coralmycin A/epi-coralmycin A, as well as a desmethoxy analogue is described. Synthesis was achieved via a divergent, bidirectional solid-phase strategy, including a key...

2015 ◽  
Vol 21 (14) ◽  
pp. 5311-5316 ◽  
Author(s):  
Hans-Dieter Arndt ◽  
Stefano Rizzo ◽  
Christina Nöcker ◽  
Vijay N. Wakchaure ◽  
Lech-Gustav Milroy ◽  
...  

2009 ◽  
Vol 109 (5) ◽  
pp. 1999-2060 ◽  
Author(s):  
Jyoti P. Nandy ◽  
Michael Prakesch ◽  
Shahriar Khadem ◽  
P. Thirupathi Reddy ◽  
Utpal Sharma ◽  
...  

2001 ◽  
Vol 66 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Kouki Kitagawa ◽  
Chikako Aida ◽  
Hidetoshi Fujiwara ◽  
Takeshi Yagami ◽  
Shiroh Futaki ◽  
...  

2004 ◽  
Vol 6 (5) ◽  
pp. 735-745 ◽  
Author(s):  
Prabhat Arya ◽  
Samuel Couve-Bonnaire ◽  
Patricia Durieux ◽  
Daisy Laforce ◽  
Rohtash Kumar ◽  
...  

Molecules ◽  
2020 ◽  
Vol 25 (2) ◽  
pp. 414 ◽  
Author(s):  
Andrea Calcaterra ◽  
Laura Mangiardi ◽  
Giuliano Delle Monache ◽  
Deborah Quaglio ◽  
Silvia Balducci ◽  
...  

The Pictet-Spengler reaction (P-S) is one of the most direct, efficient, and variable synthetic method for the construction of privileged pharmacophores such as tetrahydro-isoquinolines (THIQs), tetrahydro-β-carbolines (THBCs), and polyheterocyclic frameworks. In the lustro (five-year period) following its centenary birthday, the P-S reaction did not exit the stage but it came up again on limelight with new features. This review focuses on the interesting results achieved in this period (2011–2015), analyzing the versatility of this reaction. Classic P-S was reported in the total synthesis of complex alkaloids, in combination with chiral catalysts as well as for the generation of libraries of compounds in medicinal chemistry. The P-S has been used also in tandem reactions, with the sequences including ring closing metathesis, isomerization, Michael addition, and Gold- or Brønsted acid-catalyzed N-acyliminium cyclization. Moreover, the combination of P-S reaction with Ugi multicomponent reaction has been exploited for the construction of highly complex polycyclic architectures in few steps and high yields. The P-S reaction has also been successfully employed in solid-phase synthesis, affording products with different structures, including peptidomimetics, synthetic heterocycles, and natural compounds. Finally, the enzymatic version of P-S has been reported for biosynthesis, biotransformations, and bioconjugations.


2009 ◽  
pp. 2926 ◽  
Author(s):  
Masahito Yoshida ◽  
Christian Hedberg ◽  
Markus Kaiser ◽  
Herbert Waldmann

2000 ◽  
Vol 122 (41) ◽  
pp. 9939-9953 ◽  
Author(s):  
K. C. Nicolaou ◽  
J. A. Pfefferkorn ◽  
A. J. Roecker ◽  
G.-Q. Cao ◽  
S. Barluenga ◽  
...  

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