Metal-Free Tandem Dehydrogenative α-Arylation Reaction of Propargylic Alcohols with 2-Alkynylbenzaldoximes toward the Synthesis of α-(4-Bromo-isoquinolin-1-yl)-propenone Skeletons

A tandem reaction of 2-alkynylbenzaldoximes with propargylic alcohols has been developed for the synthesis of α-(4-bromo-isoquinolin-1-yl)-propenones. Employing 2-alkynylbenzaldoximes as a precursor in the presence of Br2 generates 4-Bromo-isoquinoline-N-oxides. Subsequently, dehydroxylation...