Transition metal-free approach to azafluoranthene scaffolds by aldol condensation/[1+2+3] annulation tandem reaction of isocyanoacetates with 8-(alkynyl)-1-naphthaldehydes

2021 ◽  
Author(s):  
Penghui Dong ◽  
Kashif Majeed ◽  
lingna Wang ◽  
Zijian Guo ◽  
Fengtao Zhou ◽  
...  
Keyword(s):  
Transition Metal ◽  
Aldol Condensation ◽  
Domino Reaction ◽  
Tandem Reaction ◽  
Metal Free ◽  
Successive Formation ◽  
General Synthesis

A transition metal-free aldol condensation/[1+2+3] annulation reaction of isocyanoacetates with 8-(alkynyl)-1-naphthaldehydes has been developed for the general synthesis of azafluoranthenes. This domino reaction enables successive formation of three new bonds...

Transition-Metal-Free, Intermolecular Azidoheteroarylation of Alkenes: Efficient Access to β-Azidoalkylated Quinoxalinones and Preliminary Antifungal Evaluation Against Magnaporthe grisea

Synthesis ◽  
2020 ◽  
Vol 52 (16) ◽  
pp. 2395-2409
Author(s):  
Weiwei Qin ◽  
Zhaodong Li ◽  
Yiming Du ◽  
Yue Chen ◽  
Yun-Lin Liu
Keyword(s):  
Transition Metal ◽  
Magnaporthe Grisea ◽  
Single Step ◽  
Domino Reaction ◽  
Efficient Synthesis ◽  
Metal Free ◽  
Efficient Access ◽  
First Time ◽  
Antibacterial Evaluation ◽  
Addition Pathway

An efficient, PhI(OAc)2-mediated, radical azidoheteroarylation of alkenes under transition-metal-free conditions is reported by employing TMSN3 and quinoxalin-2(1H)-ones as coupling partners. This domino reaction allows an efficient synthesis of valuable orangoazides containing quinoxalin-2(1H)-one derivatives and could be extended to phosphinyl-alkylated quinoxalin-2(1H)-one in a single step in moderate to excellent yields under mild conditions, as demonstrated by the preliminary antibacterial evaluation against Magnaporthe grisea for the first time. Mechanistic studies revealed that this transformation undergoes a cascade addition pathway controlled by a polar radical.

Construction of 6H-benzo[c]thiochromenes via a tandem reaction of arynes with thionoesters

2021 ◽  
Author(s):  
Yi An ◽  
Fang Zhang ◽  
Guangfen Du ◽  
Zhihua Cai ◽  
Lin He
Keyword(s):  
Transition Metal ◽  
Tandem Reaction ◽  
Tandem Reactions ◽  
Metal Free

A mild and transition-metal free method has been proposed for the synthesis of 6H-benzo[c]thiochromenes via the tandem reactions of arynes with thionoesters.

Application of primary halogenated hydrocarbons for the synthesis of 3-aryl and 3-alkyl indolizines

2017 ◽  
Vol 15 (23) ◽  
pp. 5016-5024 ◽  
Author(s):  
Yan Liu ◽  
Huayou Hu ◽  
Junyu Zhou ◽  
Wenhui Wang ◽  
Youliang He ◽  
...  
Keyword(s):  
Transition Metal ◽  
Halogenated Hydrocarbons ◽  
Tandem Reaction ◽  
Synthetic Route ◽  
Metal Free ◽  
First Time

A transition-metal-free synthetic route to 3-aryl and 3-alkyl indolizines from electron-deficient alkenes, pyridines and primary halogenated hydrocarbons is reported for the first time using a tandem reaction.

ChemInform Abstract: An Efficient, Transition-Metal-Free Process for the Synthesis of Substituted Dihydrofurans via a Michael/Cyclization Tandem Reaction.

ChemInform ◽  
2011 ◽  
Vol 42 (20) ◽  
pp. no-no
Author(s):  
Ming-Yu Wu ◽  
Ming-Qi Wang ◽  
Kun Li ◽  
Xing-Wen Feng ◽  
Ting He ◽  
...  
Keyword(s):  
Transition Metal ◽  
Tandem Reaction ◽  
Metal Free ◽  
Free Process

An efficient, transition-metal-free process for the synthesis of substituted dihydrofurans via a Michael/cyclization tandem reaction

2011 ◽  
Vol 52 (6) ◽  
pp. 679-683 ◽  
Author(s):  
Ming-Yu Wu ◽  
Ming-Qi Wang ◽  
Kun Li ◽  
Xing-Wen Feng ◽  
Ting He ◽  
...  
Keyword(s):  
Transition Metal ◽  
Tandem Reaction ◽  
Metal Free ◽  
Free Process

KOtBu-Mediated Coupling of Indoles and [60]Fullerene: Transition-Metal-Free and General Synthesis of 1,2-(3-Indole)(hydro)[60]fullerenes

2015 ◽  
Vol 80 (21) ◽  
pp. 10605-10610 ◽  
Author(s):  
Fei Li ◽  
Imad Elddin Haj Elhussin ◽  
Shengli Li ◽  
Hongping Zhou ◽  
Jieying Wu ◽  
...  
Keyword(s):  
Transition Metal ◽  
Metal Free ◽  
General Synthesis
Sign in / Sign up

Export Citation Format

Share Document