2-Pyridinylmethyl Borrowing: Base-promoted C-Alkylation of (Pyridin-2-yl)methyl Alcohols with Ketones via Cleavage of Unstrained C(sp3)–C(sp3) Bonds

2021 ◽  
Author(s):  
Chuan-Ming Hong ◽  
Fei-Fei Zou ◽  
Xin Zhuang ◽  
Zhen Luo ◽  
Zheng-Qiang Liu ◽  
...  
Keyword(s):  
Transition Metal ◽  
Environmentally Benign ◽  
Methyl Ketones ◽  
Metal Free

A transition-metal-free synthesis of β-(pyridin-2-yl)-methyl ketones, utilizing (pyridin-2-yl)methyl alcohols and ketones through 2-pyridinylmethyl borrowing strategy, has been disclosed. This approach provides an efficient, available and environmentally benign access, leading to...

Transition metal-free C(sp3)–H bond coupling among three methyl groups

2017 ◽  
Vol 53 (38) ◽  
pp. 5346-5349 ◽  
Author(s):  
Yufeng Liu ◽  
Xi Zhan ◽  
Pengyi Ji ◽  
Jingwen Xu ◽  
Qiang Liu ◽  
...  
Keyword(s):  
Transition Metal ◽  
Methyl Groups ◽  
Methyl Ketones ◽  
Reaction Conditions ◽  
Methyl Group ◽  
Metal Free

A coupling of multiple C(sp3)–H bonds of the methyl group in methyl ketones with dimethyl sulfoxides was developed under transition metal-free reaction conditions.

Transition-metal-free and organic solvent-free conversion of N-substituted 2-aminobiaryls into corresponding carbazoles via intramolecular oxidative radical cyclization induced by peroxodisulfate

2017 ◽  
Vol 19 (24) ◽  
pp. 5854-5861 ◽  
Author(s):  
Palani Natarajan ◽  
Priya Priya ◽  
Deachen Chuskit
Keyword(s):  
Transition Metal ◽  
Organic Solvent ◽  
Radical Cyclization ◽  
Solvent Free ◽  
Environmentally Benign ◽  
Metal Free ◽  
Benign Synthesis ◽  
Oxidative Radical Cyclization

An atom-economical and environmentally benign synthesis of N-substituted carbazoles is described. This methodology afforded products in 90–120 minutes.

A metal-free method for facile synthesis of indanones via intramolecular hydroacylation of 2-vinylbenzaldehydes

2021 ◽  
Author(s):  
Guoxue He ◽  
Jinyu Ma ◽  
Jianhui Zhou ◽  
Chunpu Li ◽  
Hong Liu ◽  
...  
Keyword(s):  
Transition Metal ◽  
Environmentally Benign ◽  
Facile Synthesis ◽  
Metal Free ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

A facile method access to indanones was developed under metal- and additive-free conditions in which L-proline served as efficient and environmentally benign catalysts. Compared with previous indanones synthesis by transition-metal-catalyzed...

Transition metal-free C-3 functionalization of quinoxalin-2(1H)-ones: recent advances and sanguine future

2021 ◽  
Author(s):  
Kiran ◽  
Payal Rani ◽  
Sandhya Chahal ◽  
Jayant Sindhu ◽  
Sudhir Kumar ◽  
...  
Keyword(s):  
Transition Metal ◽  
Environmentally Benign ◽  
Metal Free ◽  
Gradual Shift ◽  
Recent Advances ◽  
Metal Catalyzed

A gradual shift from metal-catalyzed to metal-free methods is occurring, as the latter are more environmentally benign. This review discusses sustainable protocols for the construction of C–C, C–N, C–P, C–S, and C–O bonds via C–H functionalization of quinoxalin-2(1H)-ones.

Transition metal free synthesis of multifunctional thiomethylated-benzenes from aryl/heteroaryl/cyclopropyl methyl ketones

Tetrahedron ◽  
2020 ◽  
Vol 76 (21) ◽  
pp. 131183 ◽  
Author(s):  
Rahul Panwar ◽  
Ismail Althagafi ◽  
Shally ◽  
Ranjay Shaw ◽  
Amr Elagamy ◽  
...  
Keyword(s):  
Transition Metal ◽  
Methyl Ketones ◽  
Metal Free

scholarly journals A Practical Synthesis of α-Aryl Methyl Ketones via a Transition-Metal-Free Meerwein Arylation.

ChemInform ◽  
2007 ◽  
Vol 38 (28) ◽  
Author(s):  
Carmela Molinaro ◽  
Jeffrey Mowat ◽  
Francis Gosselin ◽  
Paul D. O'Shea ◽  
Jean-Francois Marcoux ◽  
...  
Keyword(s):  
Transition Metal ◽  
Methyl Ketones ◽  
Metal Free ◽  
Practical Synthesis ◽  
Aryl Methyl

scholarly journals Atom-Economic Synthesis of 4-Pyrones from Diynones and Water

2017 ◽  
Author(s):  
Yan-Li Xu ◽  
Qing-Hu Teng ◽  
Wei Tong ◽  
Heng-Shan Wang ◽  
Ying-Ming Pan ◽  
...  
Keyword(s):  
Transition Metal ◽  
Nucleophilic Addition ◽  
Environmentally Benign ◽  
Metal Free ◽  
Efficient Access ◽  
Simple Atom

Transition-metal-free synthesis of 4-pyrones via TfOH-promoted nucleophilic addition/cyclization of diynones and water has been developed. This transformation is simple, atom economical and environmentally benign, providing rapid and efficient access to substituted 4-pyrones.

Dearomative C–C and C–N bond cleavage of 2-arylindoles: transition-metal-free access to 2-aminoarylphenones

2016 ◽  
Vol 3 (3) ◽  
pp. 364-367 ◽  
Author(s):  
Shuang Luo ◽  
Ziwei Hu ◽  
Qiang Zhu
Keyword(s):  
Transition Metal ◽  
Bond Cleavage ◽  
Bond Formation ◽  
Environmentally Benign ◽  
Free Access ◽  
Oxidative Dearomatization ◽  
Metal Free

A transition-metal-free conversion of 2-arylindoles to 2-aminoarylphenones, using environmentally benign O2 as the sole oxidant, has been developed. This novel oxidative dearomatization process involves cleavage of two C–C and one C–N bonds followed by new C–C and C–O bond formation.

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