Silylations of Arenes with Hydrosilanes: From Transition-Metal-Catalyzed CX Bond Cleavage to Environmentally Benign Transition-Metal-Free CH Bond Activation

ChemSusChem ◽  
2015 ◽  
Vol 8 (13) ◽  
pp. 2176-2179 ◽  
Author(s):  
Zheng Xu ◽  
Li-Wen Xu
Keyword(s):  
Transition Metal ◽  
Bond Activation ◽  
Bond Cleavage ◽  
Environmentally Benign ◽  
Metal Free ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

A metal-free method for facile synthesis of indanones via intramolecular hydroacylation of 2-vinylbenzaldehydes

2021 ◽  
Author(s):  
Guoxue He ◽  
Jinyu Ma ◽  
Jianhui Zhou ◽  
Chunpu Li ◽  
Hong Liu ◽  
...  
Keyword(s):  
Transition Metal ◽  
Environmentally Benign ◽  
Facile Synthesis ◽  
Metal Free ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

A facile method access to indanones was developed under metal- and additive-free conditions in which L-proline served as efficient and environmentally benign catalysts. Compared with previous indanones synthesis by transition-metal-catalyzed...

scholarly journals Catalyst-free arylation of sulfonamides via visible light-mediated deamination

2021 ◽  
Author(s):  
Yong Luo ◽  
Hao Ding ◽  
Jing-Song Zhen ◽  
Xian Du ◽  
Xiao-Hong Xu ◽  
...  
Keyword(s):  
Transition Metal ◽  
Visible Light ◽  
Bond Activation ◽  
Bond Cleavage ◽  
Boronic Acids ◽  
Catalyst Free ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

A novel arylation of sulfonamides with boronic acids to afford various diaryl sulfones via visible light-mediated N–S bond cleavage other than typical transition-metal-catalyzed C(O)–N bond activation is described. This methodology...

A reaction of [2,6-(tBu2PO)2C6H3]NiSCH2Ph with BH3·THF: borane mediated C–S bond cleavage

2018 ◽  
Vol 47 (17) ◽  
pp. 6018-6024 ◽  
Author(s):  
Jie Zhang ◽  
Ting Liu ◽  
Qiang-Qiang Ma ◽  
Shujun Li ◽  
Xuenian Chen
Keyword(s):  
Transition Metal ◽  
Bond Activation ◽  
Bond Cleavage ◽  
Suitable Model ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

C–S bond cleavage of the thiolato ligand of [2,6-(tBu2PO)2C6H3]NiSCH2Ph mediated by BH3 as a suitable model for the transition metal catalyzed C–S bond activation of mercaptans.

Developments in Organocatalyzed C(Ar)- C(Ar) Bond formation Reactions via Single Electron Transfer Mechanism: An Overview

2021 ◽  
Vol 08 ◽  
Author(s):  
Lalit Yadav ◽  
Sandeep Chaudhary
Keyword(s):  
Transition Metal ◽  
Organic Synthesis ◽  
Bond Activation ◽  
Bond Formation ◽  
Cross Coupling ◽  
Coupling Reactions ◽  
Metal Free ◽  
Cross Coupling Reactions ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

: The formation of new bonds through C-C bond formation is of utmost importance in the synthesis of biologically privileged scaffolds and therapeutic drugs. In recent years, extensive efforts has been done to improve the intermolecular and intramolecular cross-coupling reaction in the simple, mild, efficient, economical, and eco-friendly manner via transition metal-free or organocatalytic direct C-H bond activation methodology. The traditional crosscoupling era continuously shifted to metal-free, organocatalytic, or metal-free cross-dehydrogenative coupling strategies to fast-track the reactions and diminishing the typical purification processes. Therefore, recent advances on the transitionmetal-free, organocatalytic inter- and intra-molecular cross-coupling reactions have been introduced and discussed in the present article. In view of the reaction mechanism, organocatalytic cross-coupling reactions undergo through the radical pathways, radical anionic intermediate which is completely different from traditional transition metal-catalyzed reactions. The exploration of transition metal-free organocatalyzed cross-couplings for direct C-H arylation of arenes has grown significantly, thereby, improving the formation of a wide range of aryl-aryl /aryl-heteroaryl/ heteroaryl-heteroaryl compounds. In the survey, transition metal-free/organocatalytic cross-coupling reactions showed a higher efficiency under simple and mild conditions than the comparative transition metal-catalyzed cross-coupling reactions. However, the higher regioselectivity and chemoselectivity are still far ahead in organocatalytic cross-coupling reactions due to their specific intrinsic mechanistic pathway. The tuning of many parameters such as oxidative states, ligands coordination, and counter anions, etc., which results in the specific direct C-H functionalization with flexible methodology are missing in the transition metal-free cross-coupling reactions. The highly systematic transition metal-catalyzed chemistry is still playing a dominant role over transition metal-free chemistry in organic synthesis. The organocatalyzed transition-metal-free conditions should be more efficient, chemoselective, and regioselective for further potential development and applications in organic synthesis. For the endless pursuit of sustainable chemistry and green chemistry, such transition-metalfree/organocatalytic reactions should be never ceased. Additional curious attention and interest have been developed so far, and chemists are showing their eagerness and talents to uncover the hidden treasure of green chemistry. In this review article, we highlighted the developments of various transition metal-free/organocatalytic C-H bond activation reactions which further encourages the advancement in the development of sustainable C-C coupling reactions and their further applications towards the synthesis of biologically privileged scaffolds and drug molecules.

Transition-Metal-Catalyzed Oxidative and Decarboxylative Acylations through sp2 C-H Bond Activation

2015 ◽  
Vol 20 (5) ◽  
pp. 471-511 ◽  
Author(s):  
Satyasheel Sharma ◽  
Neeraj Kumar Mishra ◽  
Youngmi Shin ◽  
In Su Kim
Keyword(s):  
Transition Metal ◽  
Bond Activation ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed

Transition metal-catalyzed arylation of unstrained C−C single bonds

2021 ◽  
Author(s):  
Long Yang ◽  
Wuxin Zhou ◽  
Qiang Li ◽  
Xiangge Zhou
Keyword(s):  
Organic Chemistry ◽  
Transition Metal ◽  
Bond Activation ◽  
Important Research ◽  
Carbon Bond ◽  
Research Areas ◽  
Carbon Carbon Bond ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed ◽  
Single Bonds

Carbon−carbon bond activation is one of the most challenging and important research areas in organic chemistry. Selective C−C bond activation of unstrained substrates is difficult to achieve owing to its...

Transition-Metal-Catalyzed Transformation of Sulfonates via S–O Bond Cleavage: Synthesis of Alkyl Aryl Ether and Diaryl Ether

2019 ◽  
Vol 21 (22) ◽  
pp. 8879-8883 ◽  
Author(s):  
Xuemeng Chen ◽  
Xue Xiao ◽  
Haotian Sun ◽  
Yue Li ◽  
Haolin Cao ◽  
...  
Keyword(s):  
Transition Metal ◽  
Bond Cleavage ◽  
Aryl Ether ◽  
Alkyl Aryl ◽  
Diaryl Ether ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed
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