Towards 4th industrial revolution efficient and sustainable continuous flow manufacturing of active pharmaceutical ingredients

2022 ◽  
Author(s):  
Cloudius Sagandira ◽  
Sinazo Nqeketo ◽  
Kanysile Mhlana ◽  
Thembela Sonti ◽  
Paul Watts ◽  
...  
Keyword(s):  
Pharmaceutical Industry ◽  
Continuous Flow ◽  
Industrial Revolution ◽  
Flow Chemistry ◽  
Active Pharmaceutical Ingredients ◽  
New Paradigm ◽  
Pharmaceutical Ingredients ◽  
Continuous Flow Chemistry

Continuous flow chemistry has opened a new paradigm in both the laboratory and pharmaceutical industry. This review details the recently reported literature on continuous multistep telescoped synthesis of active pharmaceutical...

scholarly journals Impact of continuous flow chemistry in the synthesis of natural products and active pharmaceutical ingredients

2018 ◽  
Vol 90 (1 suppl 2) ◽  
pp. 1131-1174 ◽  
Author(s):  
JULIANA M. DE SOUZA ◽  
RENAN GALAVERNA ◽  
ALINE A.N. DE SOUZA ◽  
TIMOTHY J. BROCKSOM ◽  
JULIO C. PASTRE ◽  
...  
Keyword(s):  
Natural Products ◽  
Continuous Flow ◽  
Flow Chemistry ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Continuous Flow Chemistry

15.1 Flow Chemistry in the Pharmaceutical Industry: Part 1

2018 ◽  
Author(s):  
A. G. O’Brien
Keyword(s):  
Pharmaceutical Industry ◽  
Large Scale ◽  
Flow Chemistry ◽  
Active Pharmaceutical Ingredients ◽  
Flow Process ◽  
Pharmaceutical Ingredients ◽  
Multistep Synthesis

Abstract The use of flow chemistry in the single- and multistep synthesis of active pharmaceutical ingredients has been well demonstrated. The pharmaceutical industry is now taking the next steps towards integration of flow chemistry into large-scale commercialized processes, which can effectively supply patient populations. This chapter details advances in this area, and outlines the data and knowledge required to select, develop, scale, and commercialize an efficient flow process.

scholarly journals The synthesis of active pharmaceutical ingredients (APIs) using continuous flow chemistry

2015 ◽  
Vol 11 ◽  
pp. 1194-1219 ◽  
Author(s):  
Marcus Baumann ◽  
Ian R Baxendale
Keyword(s):  
Continuous Flow ◽  
Large Scale ◽  
Systems Approach ◽  
Flow Chemistry ◽  
Innovative Technology ◽  
Enabling Technology ◽  
Flow Reactors ◽  
Pharmaceutical Ingredients ◽  
Continuous Flow Chemistry ◽  
Line Analysis

The implementation of continuous flow processing as a key enabling technology has transformed the way we conduct chemistry and has expanded our synthetic capabilities. As a result many new preparative routes have been designed towards commercially relevant drug compounds achieving more efficient and reproducible manufacture. This review article aims to illustrate the holistic systems approach and diverse applications of flow chemistry to the preparation of pharmaceutically active molecules, demonstrating the value of this strategy towards every aspect ranging from synthesis, in-line analysis and purification to final formulation and tableting. Although this review will primarily concentrate on large scale continuous processing, additional selected syntheses using micro or meso-scaled flow reactors will be exemplified for key transformations and process control. It is hoped that the reader will gain an appreciation of the innovative technology and transformational nature that flow chemistry can leverage to an overall process.

scholarly journals A Perspective on Continuous Flow Chemistry in the Pharmaceutical Industry

2020 ◽  
Vol 24 (10) ◽  
pp. 1802-1813 ◽  
Author(s):  
Marcus Baumann ◽  
Thomas S. Moody ◽  
Megan Smyth ◽  
Scott Wharry
Keyword(s):  
Pharmaceutical Industry ◽  
Continuous Flow ◽  
Flow Chemistry ◽  
Continuous Flow Chemistry

scholarly journals Application of Reactor Engineering Concepts in Continuous Flow Chemistry: A Review

2021 ◽  
Author(s):  
Nicole Candice Neyt ◽  
Darren Lyall Riley
Keyword(s):  
Rapid Growth ◽  
Continuous Flow ◽  
Flow Chemistry ◽  
The Past ◽  
Continuous Flow Chemistry

The adoption of flow technology for the manufacture of chemical entities, and in particular pharmaceuticals, has seen rapid growth over the past two decades with the technology now blurring the...

scholarly journals Continuous-flow chemistry in chemical education

2017 ◽  
Vol 7 (3–4) ◽  
pp. 157-158 ◽  
Author(s):  
Daniel Blanco-Ania ◽  
Floris P. J. T. Rutjes
Keyword(s):  
Continuous Flow ◽  
Chemical Education ◽  
Flow Chemistry ◽  
Continuous Flow Chemistry

ChemInform Abstract: Continuous Flow Chemistry: A Discovery Tool for New Chemical Reactivity Patterns.

ChemInform ◽  
2014 ◽  
Vol 45 (44) ◽  
pp. no-no
Author(s):  
Jan Hartwig ◽  
Jan B. Metternich ◽  
Nikzad Nikbin ◽  
Andreas Kirschning ◽  
Steven V. Ley
Keyword(s):  
Continuous Flow ◽  
Chemical Reactivity ◽  
Flow Chemistry ◽  
Continuous Flow Chemistry

scholarly journals Scalable Synthesis of Norbornadienes via in situ Cracking of Dicyclopentadiene Using Continuous Flow Chemistry

2021 ◽  
Author(s):  
Jessica Orrego‐Hernández ◽  
Helen Hölzel ◽  
Maria Quant ◽  
Zhihang Wang ◽  
Kasper Moth‐Poulsen
Keyword(s):  
Continuous Flow ◽  
Flow Chemistry ◽  
Continuous Flow Chemistry ◽  
Scalable Synthesis
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