Clay-based nanocomposite hydrogel with attractive mechanical properties and sustained bioactive ion release for bone defect repair

2021 ◽  
Author(s):  
Xinyun Zhai ◽  
Changshun Ruan ◽  
Jie Shen ◽  
Chuping Zheng ◽  
Xiaoli Zhao ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Bone Defect ◽  
Nanocomposite Hydrogel ◽  
Ion Release ◽  
Bone Defect Repair ◽  
Defect Repair ◽  
Gradual Release

Using nanoclay as the physical crosslinker, a novel clay-based nanocomposite hydrogel with attractive mechanical properties has be obtained, and the gradual release of intrinsic Mg2+ and Si4+ endows the system with excellent osteogenesis.

scholarly journals Hydroxyapatite nanowire/collagen elastic porous nanocomposite and its enhanced performance in bone defect repair

RSC Advances ◽  
2018 ◽  
Vol 8 (46) ◽  
pp. 26218-26229 ◽  
Author(s):  
Tuan-Wei Sun ◽  
Ying-Jie Zhu ◽  
Feng Chen
Keyword(s):  
Mechanical Properties ◽  
Bone Defect ◽  
Bone Defect Repair ◽  
Defect Repair ◽  
Porous Nanocomposite

The biomimetic porous nanocomposite comprising ultralong hydroxyapatite nanowires and collagen exhibits significantly enhanced mechanical properties and superior bone defect repair performance.

scholarly journals Tuning filament composition and microstructure of 3D-printed bioceramic scaffolds facilitate bone defect regeneration and repair

2021 ◽  
Vol 8 (2) ◽  
Author(s):  
Yi Chen ◽  
Jiaping Huang ◽  
Jiamei Liu ◽  
Yingming Wei ◽  
Xianyan Yang ◽  
...  
Keyword(s):  
3D Printing ◽  
Bone Defect ◽  
Core Shell ◽  
Shell Layer ◽  
Ion Release ◽  
Component Distribution ◽  
Bone Defect Repair ◽  
Defect Repair

Abstract It is still a challenge to optimize the component distribution and microporous structures in scaffolds for tailoring biodegradation (ion releasing) and enhancing bone defect repair within an expected time stage. Herein, the core–shell-typed nonstoichiometric wollastonite (4% and 10% Mg-doping calcium silicate; CSiMg4, CSiMg10) macroporous scaffolds with microporous shells (adding ∼10 μm PS microspheres into shell-layer slurry) were fabricated via 3D printing. The initial mechanical properties and bio-dissolution (ion releasing) in vitro, and osteogenic capacity in vivo of the bioceramic scaffolds were evaluated systematically. It was shown that endowing high-density micropores in the sparingly dissolvable CSiMg10 or dissolvable CSiMg4 shell layer inevitably led to nearly 30% reduction of compressive strength, but such micropores could readily tune the ion release behaviour of the scaffolds (CSiMg4@CSiMg10 vs. CSiMg4@CSiMg10-p; CSiMg10@CSiMg4 vs. CSiMg10@CSiMg4-p). Based on the in rabbit femoral bone defect repair model, the 3D μCT reconstruction and histological observation demonstrated that the CSiMg4@CSiMg10-p scaffolds displayed markedly higher osteogenic capability than the other scaffolds after 12 weeks of implantation. It demonstrated that core–shell bioceramic 3D printing technique can be developed to fabricate single-phase or biphasic bioactive ceramic scaffolds with accurately tailored filament biodegradation for promoting bone defect regeneration and repair in some specific pathological conditions.

scholarly journals Bone defect repair on the alveolar wall of the maxillary sinus using collagen membranes and temporal fascia: an experimental study in monkeys

2011 ◽  
Vol 77 (4) ◽  
pp. 439-446 ◽  
Author(s):  
Adalberto Novaes Silva ◽  
José Américo de Oliveira ◽  
Maria Célia Jamur ◽  
José Ari Gualberto Junqueira ◽  
Vani Maria Correa ◽  
...  
Keyword(s):  
Experimental Study ◽  
Maxillary Sinus ◽  
Bone Defect ◽  
Alveolar Wall ◽  
Bone Defect Repair ◽  
Temporal Fascia ◽  
Defect Repair ◽  
Collagen Membranes

Injectable gel graft for bone defect repair

2014 ◽  
Vol 9 (1) ◽  
pp. 41-51 ◽  
Author(s):  
Josephine Fang ◽  
Zhi Yang ◽  
ShihJye Tan ◽  
Charisse Tayag ◽  
Marcel E Nimni ◽  
...  
Keyword(s):  
Bone Defect ◽  
Bone Defect Repair ◽  
Defect Repair

Nano-Hydroxyapatite Scaffold Based on Recombinant Human Bone Morphogenetic Protein 2 and Its Application in Bone Defect Repair

2021 ◽  
Vol 17 (7) ◽  
pp. 1330-1338
Author(s):  
Shibai Zhu ◽  
Xiaotian Zhang ◽  
Xi Chen ◽  
Yiou Wang ◽  
Shanni Li ◽  
...  
Keyword(s):  
Bone Defect ◽  
Bone Defects ◽  
Bone Morphogenetic Protein 2 ◽  
Artificial Bone ◽  
Bone Defect Repair ◽  
Morphogenetic Protein ◽  
Human Bone Morphogenetic Protein ◽  
Defect Repair ◽  
Hydroxyapatite Scaffold ◽  
Recombinant Human Bone

The best way in which to prepare scaffolds with good biological properties is an urgent problem in the field of tissue engineering. In this paper we discuss the preparation of nano-hydroxyapatite scaffold of recombinant human bone morphogenetic protein-2 (rhBMP-2) and its application in bone defect repair. rhBMP-2 reagent was dissolved in 1 mol/L sodium dihydrogen phosphate solution, and the rhBMP-2 solution was added to the nano-hydroxyapatite artificial bone with a 100 μL glass micro dropper at the rate of 10 drops/min to obtain Nano-HA/rhBMP-2 composite artificial bone. In in vivo experiments, rabbits were fixed on an operating table, a 2 cm longitudinal incision was made in the middle part of the radial forearm, and the radius was cut with a wire saw and periosteum, 2.5 cm away from the distal radius. After washing the wound with normal saline, Adv-hBMP-2/MC3T3-E1 nano-HA composite artificial bone, MC3T3-E1 nan-HA composite artificial bone, or Nano-HA artificial bone were implanted in different groups. The artificial bone scaffold prepared in this study has a stronger ability to repair bone defects than the alternatives, and is a promising prospect for the clinical treatment of bone defects.

Local Elimination of Senescent Cells Promotes Bone Defect Repair during Aging

2022 ◽  
Author(s):  
Xiaotao Xing ◽  
Haisen Huang ◽  
Xin Gao ◽  
Jian Yang ◽  
Qi Tang ◽  
...  
Keyword(s):  
Bone Defect ◽  
Bone Defect Repair ◽  
Defect Repair

PLGA/TCP composite scaffold incorporating bioactive phytomolecule icaritin for enhancement of bone defect repair in rabbits

2013 ◽  
Vol 9 (5) ◽  
pp. 6711-6722 ◽  
Author(s):  
S.-H. Chen ◽  
M. Lei ◽  
X.-H. Xie ◽  
L.-Z. Zheng ◽  
D. Yao ◽  
...  
Keyword(s):  
Bone Defect ◽  
Composite Scaffold ◽  
Bone Defect Repair ◽  
Defect Repair

Animal Models of Bone Defect Repair

2020 ◽  
pp. 241-260
Author(s):  
Yuehuei H. An ◽  
Richard J. Friedman
Keyword(s):  
Animal Models ◽  
Bone Defect ◽  
Bone Defect Repair ◽  
Defect Repair
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