Regulator of G-protein signalling and GoLoco proteins suppress TRPC4 channel function via acting at Gαi/o
Keyword(s):
Transient receptor potential canonical 4 (TRPC4) form Ca2+-permeable cation channels activated downstream from receptor-activated Gi/o signalling. We show here that regulator of G-protein signalling (RGS) and Gαi/o-Loco (GoLoco) domain proteins suppress TRPC4 currents probably through regulation of lifetime and availability of Gαi/o-GTP, revealing new components of receptor-operated channel function.
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