The regulation of transient receptor potential canonical 4 (TRPC4) channel by phosphodiesterase 5 inhibitor via the cyclic guanosine 3′5′-monophosphate

2017 ◽  
Vol 469 (5-6) ◽  
pp. 693-702 ◽  
Author(s):  
Jinhong Wie ◽  
SeungJoo Jeong ◽  
Misun Kwak ◽  
Jongyun Myeong ◽  
MeeRee Chae ◽  
...  
Keyword(s):  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Phosphodiesterase 5 Inhibitor ◽  
Transient Receptor Potential Canonical ◽  
Trpc4 Channel ◽  
Transient Receptor ◽  
Phosphodiesterase 5

scholarly journals Regulator of G-protein signalling and GoLoco proteins suppress TRPC4 channel function via acting at Gαi/o

2016 ◽  
Vol 473 (10) ◽  
pp. 1379-1390 ◽  
Author(s):  
Jae-Pyo Jeon ◽  
Dhananjay P. Thakur ◽  
Jin-bin Tian ◽  
Insuk So ◽  
Michael X. Zhu
Keyword(s):  
G Protein ◽  
Transient Receptor Potential ◽  
Receptor Potential ◽  
Cation Channels ◽  
Transient Receptor Potential Canonical ◽  
Channel Function ◽  
G Protein Signalling ◽  
Trpc4 Channel ◽  
Transient Receptor

Transient receptor potential canonical 4 (TRPC4) form Ca2+-permeable cation channels activated downstream from receptor-activated Gi/o signalling. We show here that regulator of G-protein signalling (RGS) and Gαi/o-Loco (GoLoco) domain proteins suppress TRPC4 currents probably through regulation of lifetime and availability of Gαi/o-GTP, revealing new components of receptor-operated channel function.

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