An aspartic acid residue at the active site of pepsin. The isolation and sequence of the heptapeptide
Keyword(s):
Pepsin reacts stoicheiometrically with the active-site-directed irreversible inhibitor N-diazoacetyl-l-phenylalanine methyl ester, with concomitant loss of all proteolytic and peptidolytic activity. The reagent esterifies a unique aspartic acid residue in pepsin, which is in the sequence:Ile-Val-Asp-Thr-Gly-Thr-Ser
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1980 ◽
Vol 45
(7)
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pp. 2131-2134
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1974 ◽
Vol 52
(11)
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pp. 1018-1023
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1970 ◽
Vol 48
(9)
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pp. 1014-1016
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2013 ◽
Vol 288
(29)
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pp. 21367-21375
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