The mass-spectrometric identification of hypoxanthine and xanthine (‘oxypurines’) in skeletal muscle from two patients with congenital xanthine oxidase deficiency (xanthinuria)
Keyword(s):
1. The presence of hypoxanthine and xanthine in the skeletal muscle of two patients with congenital xanthine oxidase deficiency (xanthinuria) was demonstrated by high-resolution mass spectrometry. 2. Evidence was obtained for the presence of a trace of hypoxanthine only in normal muscle. 3. Dry pulverized tissue was introduced directly into the mass spectrometer and preliminary chemical processing of the tissue was therefore unnecessary. 4. The criteria for the mass-spectrometric identification of hypoxanthine and xanthine in the tissue and the significance of the observations are discussed.
2010 ◽
Vol 44
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pp. 4766-4774
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2020 ◽
Vol 191
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pp. 113490
2010 ◽
Vol 404
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pp. 197-203
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1999 ◽
Vol 274
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pp. 30580-30588
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1986 ◽
Vol 381
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pp. 75-82