Enhancement of glucagon secretion from isolated rat islets of Langerhans by phorbol 12-myristate 13-acetate
Keyword(s):
Kinase C
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The phorbol ester 4 beta-phorbol 12-myristate 13-acetate (PMA), at concentrations of 0.1 microM and above, stimulated secretion of glucagon and of insulin from isolated rat islets of Langerhans incubated in the presence of 5.5 mM-glucose. Stimulation of secretion of both hormones by 1 microM-PMA persisted in the absence of external Ca2+, and could be abolished by incubating the islets at 4 degrees C. These findings suggest a role of protein kinase C in the alpha-cell (and beta-cell) secretory mechanism.
1987 ◽
Vol 50
(1-2)
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pp. 37-44
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1997 ◽
Vol 236
(1)
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pp. 162-166
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1977 ◽
Vol 154
(2)
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pp. 210-214
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1976 ◽
Vol 71
(3)
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pp. 840-844
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Keyword(s):
Keyword(s):
1992 ◽
Vol 43
(8)
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pp. 1859-1864
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