Fatty Acid Composition of Cholesterol Esters in Congenital Disorders of Lambs and Piglets

1974 ◽  
Vol 2 (2) ◽  
pp. 290-292 ◽  
Author(s):  
DENIS SWEASEY ◽  
DERYCK S. P. PATTERSON
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Congenital Disorders ◽  
Cholesterol Esters

The risk to develop NIDDM is related to the fatty acid composition of the serum cholesterol esters

Diabetes ◽  
1994 ◽  
Vol 43 (11) ◽  
pp. 1353-1357 ◽  
Author(s):  
B. Vessby ◽  
A. Aro ◽  
E. Skarfors ◽  
L. Berglund ◽  
I. Salminen ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Serum Cholesterol ◽  
Cholesterol Esters

Accumulated lipids, aberrant fatty acid composition and defective cholesterol ester hydrolase activity in cholesterol ester storage disease

2000 ◽  
Vol 37 (2) ◽  
pp. 187-193 ◽  
Author(s):  
Toru Todoroki ◽  
Kojiro Matsumoto ◽  
Kiyoaki Watanabe ◽  
Yukio Tashiro ◽  
Makoto Shimizu ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Cholesterol Ester ◽  
Storage Disease ◽  
Control Level ◽  
Hydrolase Activity ◽  
Cholesterol Esters ◽  
Cholesterol Ester Hydrolase ◽  
Ester Hydrolase

We confirmed accumulation of glycogen and lipids, particularly cholesterol esters, in the liver of a patient with cholesterol ester storage disease (CESD). Hepatic cholesterol ester concentration was 100-200 times that found in normal livers. Analysis of the fatty acid composition indicated a higher proportion (41%) of cholesterol linoleate (C18-2), a slightly lower proportion (33%) of cholesterol oleate (C18-1) and normal proportions (14%) of cholesterol palmitate (C16-0) in the CESD patient compared with the control. This fatty acid composition of cholesterol esters and the fatty acid composition of other classes of lipids in the patient's liver resembled that of LDL. We also found that acid cholesterol ester hydrolase activity in the CESD liver was reduced to 5% of that in the control liver, while neutral cholesterol ester hydrolase activity remained at the control level. These results suggest that accumulated cholesterol esters were derived mainly from serum LDL and that the accumulation resulted from lack of acid cholesterol ester hydrolase.

The Risk to Develop NIDDM Is Related to the Fatty Acid Composition of the Serum Cholesterol Esters

Diabetes ◽  
1994 ◽  
Vol 43 (11) ◽  
pp. 1353-1357 ◽  
Author(s):  
B. Vessby ◽  
A. Aro ◽  
E. Skarfors ◽  
L. Berglund ◽  
I. Salminen ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Serum Cholesterol ◽  
Cholesterol Esters
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