Effect of lectins on the free-radical processes in erythrocyte membranes in insulin dependent diabetes mellitus (IDDM)

2000 ◽  
Vol 28 (5) ◽  
pp. A397-A397
Author(s):  
R. A. Kireev ◽  
Yu. V. Yegorova ◽  
N. A. Kurmacheva ◽  
U. Yu. Melnikova ◽  
L. V. Karpunina
Keyword(s):  
Diabetes Mellitus ◽  
Free Radical ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Erythrocyte Membranes ◽  
Dependent Diabetes Mellitus ◽  
Free Radical Processes ◽  
Insulin Dependent ◽  
Radical Processes

Poor Glycaemic Control is Associated with Reduced Serum Free Radical Scavenging (Antioxidant) Activity in Non-Insulin-Dependent Diabetes Mellitus

1997 ◽  
Vol 34 (6) ◽  
pp. 638-644 ◽  
Author(s):  
S R J Maxwell ◽  
H Thomason ◽  
D Sandler ◽  
C LeGuen ◽  
M A Baxter ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Free Radical ◽  
Glycaemic Control ◽  
Radical Scavenging ◽  
Inverse Correlation ◽  
Insulin Dependent Diabetes Mellitus ◽  
Free Radical Scavenging ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent

The diabetic patient is at significantly increased risk of developing vascular disease. Its aetiology may involve oxidative damage by free radicals and protection against such damage can be offered by radical-scavenging antioxidants. We investigated whether there was a relationship between glycaemic control as assessed by measurement of glycated haemoglobin (HbAlc) and serum antioxidant status in a population of 118 diabetic outpatients with either insulin-dependent or non-insulin-dependent diabetes. Amongst patients with non-insulin-dependent diabetes mellitus there was a significant inverse correlation between levels of glycated haemoglobin and total free radical scavenging activity ( r = −0·456, P <0·0001). This association resulted primarily because of a similar correlation with uric acid ( r = −0·421, P = 0·0003). There was also a weak inverse correlation with vitamin A but no significant association with vitamin C or vitamin E levels. There were no significant associations found amongst the patients with insulin-dependent diabetes. These results indicate that poor diabetic control is associated with reduced serum free radical scavenging (antioxidant) activity in non-insulin-dependent diabetes mellitus. By implication improved glycaemic control may preserve serum antioxidant status in diabetes.

Free radical activity during development of insulin-dependent diabetes mellitus in the rat

Life Sciences ◽  
1992 ◽  
Vol 50 (5) ◽  
pp. 335-339 ◽  
Author(s):  
Olli M. Pitkänen ◽  
Julio M. Martin ◽  
Mikko Hallman ◽  
Hans K. Åkerblom ◽  
Hannu Sariola ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Free Radical ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent ◽  
Free Radical Activity

Effect of Gliclazide on Free Radical Mediated Oxidation Products in Non-Insulin Dependent Diabetes Mellitus

1988 ◽  
Vol 74 (s18) ◽  
pp. 26P-27P
Author(s):  
CM Florkowski ◽  
MR Richardson ◽  
C Leguen ◽  
PE Jennings ◽  
AF Jones ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Free Radical ◽  
Insulin Dependent Diabetes Mellitus ◽  
Oxidation Products ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Insulin Dependent ◽  
Mediated Oxidation

Elevated Circulating P-Selectin in Insulin Dependent Diabetes Mellitus

1996 ◽  
Vol 76 (03) ◽  
pp. 328-332 ◽  
Author(s):  
Bernd Jilma ◽  
Peter Fasching ◽  
Christine Ruthner ◽  
Anna Rumplmayr ◽  
Sabine Ruzicka ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Plasma Levels ◽  
Plasma Concentrations ◽  
Insulin Dependent Diabetes Mellitus ◽  
Interquartile Range ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Intergroup Comparison ◽  
Median Plasma ◽  
Insulin Dependent

SummaryBased on findings that showed increased P-selectin expression on platelets and on choroidal microvessels of patients with insulin dependent diabetes mellitus (IDDM), we hypothesized that also plasma concentrations of circulating (c)P-selectin would be increased in these patients.The aim of this study was to compare the plasma levels of cP-selec-tin between non-smoking patients with IDDM, treated with an intensified insulin therapy, and healthy controls. The study design was prospective, cross-sectional and analyst-blinded. Subjects were matched individually for sex, age and body mass index. Plasma levels of cP-selectin and of von Willebrand antigen (vWF-Ag) were determined by enzyme linked immunoassays.Forty-two pairs were available for intergroup comparison. Median plasma concentrations of cP-selectin in patients with IDDM (285 ng/ml; interquartile range: 233-372) were on average 21% higher than those of controls (236 ng/ml; interquartile range: 175-296; p = 0.004). Also, median plasma levels of vWF-Ag were 10% higher in patients (96 U/dl; interquartile range: 82-127) than controls (87 U/dl; interquartile range: 70-104; p = 0.025). There was no correlation between plasma concentrations of cP-selectin and vWF-Ag levels in either group (p ώ0.05).In conclusion, our results of increased cP-selectin levels are in line with increased P-selectin expression on platelets and on choroidal microvessels found in patients with IDDM. In view of the currently developed small molecule inhibitors of cell adhesion molecules, these independent observations together may provide a sound rationale to select P-selectin as a target for treating or preventing IDDM-associated micro- or macrovascular complications.

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