Pro-survival signalling from the NMDA receptor
2006 ◽
Vol 34
(5)
◽
pp. 936-938
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Keyword(s):
Ca2+ influx through the NMDA (N-methyl-D-aspartate) subtype of ionotropic glutamate receptors plays a Jekyll and Hyde role in the mammalian central nervous system. While it mediates excitotoxic death triggered by stroke and other acute trauma, there is growing evidence that physiological levels of NMDA receptor activity promote survival. Understanding the mechanisms that underlie these opposing effects may lead to strategies to selectively block pro-death signalling, which could have considerable clinical benefits.
2019 ◽
Vol 10
(3)
◽
pp. 228-236
◽
2004 ◽
Vol 19
(5)
◽
pp. 343-360
◽
1998 ◽
Vol 54
(5)
◽
pp. 581-618
◽
2006 ◽
Vol 572
(2)
◽
pp. 323-334
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Keyword(s):
1993 ◽
Vol 73
(3)
◽
pp. 583-616
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