The Correction of Essential Fatty Acid Deficiency and ‘Sticky’ Platelets in Man by the Cutaneous Administration of Sunflower Seed Oil

1974 ◽  
Vol 46 (2) ◽  
pp. 13P-13P
Author(s):  
Martin Press ◽  
Peter J. Hartop ◽  
Christine Hawkey
PEDIATRICS ◽  
1976 ◽  
Vol 58 (5) ◽  
pp. 650-654
Author(s):  
Zvi Friedman ◽  
Stephen J. Shochat ◽  
M. Jeffrey Maisels ◽  
Keith H. Marks ◽  
Edward L. Lamberth

Two newborn infants receiving long-term, fat-free parenteral nutrition developed essential fatty acid (EFA) deficiency. Biochemical evidence of EFA deficiency was documented in plasma, red blood cells, and adipose tissue and included a decrease in arachidonic and linoleic acids, an increase in 5,8,11-eicosatrienoic acid, palmitoleic and oleic acids and a trienoic/tetraenoic ratio of more than 0.4. Cutaneous application of sunflower-seed oil, a source rich in the essential fat linoleic acid, rapidly reversed the clinical and biochemical manifestations of deficiency in plasma.


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