Fasting and post-prandial splanchnic blood flow is reduced by a somatostatin analogue (octreotide) in man

1991 ◽  
Vol 81 (2) ◽  
pp. 169-175 ◽  
Author(s):  
A. M. Cooper ◽  
G. D. Braatvedt ◽  
M. I. Qamar ◽  
H. Brown ◽  
D. M. Thomas ◽  
...  
Keyword(s):  
Blood Flow ◽  
Superior Mesenteric Artery ◽  
Mesenteric Artery ◽  
Venous Blood ◽  
Splanchnic Blood Flow ◽  
Somatostatin Analogue ◽  
Venous Blood Flow ◽  
Blood Flows ◽  
Portal Venous Blood ◽  
Mesenteric Artery Blood Flow

1. The effects of the subcutaneous administration of a long-acting somatostatin analogue (octreotide) or of placebo on the splanchnic blood flow response to a mixed solid meal has been examined in eight normal subjects by using a transcutaneous Doppler ultrasound technique. Each subject was studied on two occasions more than 1 week apart. 2. On the control day, feeding had a pronounced effect on both superior mesenteric artery and portal venous blood flows, causing a peak rise of 82% in superior mesenteric artery blood flow at 15 min and of 75% in portal venous blood flow at 30 min post-prandially (P < 0.001). Blood flows remained elevated 2 h after the meal. Pulse and blood pressure showed no significant changes from baseline. 3. Octreotide reduced fasting superior mesenteric artery blood flow by 59% (P < 0.05) and portal venous blood flow by 49% (P < 0.01) and blunted the normal post-prandial rise. Pulse and blood pressure did not change in response to either the injection or the ingestion of the meal. 4. Octreotide suppressed the release of insulin, glucagon and pancreatic polypeptide in response to feeding and resulted in post-prandial hyperglycaemia. 5. The mechanism of action of octreotide on splanchnic blood flow is uncertain. It may be mediated via a direct vascular effect or it may act via suppression of vasoactive intestinal hormones.

Portal and splanchnic haemodynamics in patients with advanced post-hepatitic cirrhosis and in healthy adults

1998 ◽  
Vol 39 (2) ◽  
pp. 152-156
Author(s):  
H. Dinç ◽  
A. Sari ◽  
H. Resit Gümele ◽  
N. Cihanyurdu ◽  
A. Baki
Keyword(s):  
Blood Flow ◽  
Portal Vein ◽  
Venous Blood ◽  
Resistive Index ◽  
Venous Blood Flow ◽  
Blood Flows ◽  
Portal Venous Blood Flow ◽  
Portal Venous Blood ◽  
The Mean ◽  
Duplex Doppler

Purpose: to assess portal and splanchnic haemodynamics, and splanchnic vascular resistance in patients with advanced post-hepatitic cirrhosis and in healthy volunteers, by means of duplex Doppler ultrasound (US) Material and Methods: the duplex Doppler US examination was performed in 16 patients with cirrhosis and in 24 healthy volunteers. We investigated vessel diameters, mean flow velocities, and mean blood flows in the portal vein, the superior mesenteric artery (SMA), and the splenic artery (SA), and measured the resistive index values of SMA and SA Results: the mean portal venous blood flow in patients with cirrhosis (829 ± 264 ml/min) was not statistically different from those in the volunteers (734 ± 194 ml/min). the ratio of the SMA and SA blood flows (621 ml/min) to the portal venous blood flow (734 ml/min) was 0.85 in the control subjects. the mean portal venous blood flow (1261 ml/min) and the portal venous velocity (14.6 cm/s) were higher in the patients with recanalized para-umbilical veins than in the volunteers and in the patients without recanalized para-umbilical veins. the SMA and SA blood flows were significantly increased in patients with cirrhosis compared with volunteers. Splanchnic inflow (the sum of the SMA and SA blood flows) was higher than the portal blood flow in patients with cirrhosis except in the subjects with recanalized para-umbilical veins. SMA and SA resistive index values were significantly higher in these patients than in the volunteers Conclusion: Splanchnic blood flow and splanchnic vascular impedance increased significantly in patients with advanced post-hepatitic cirrhosis. Splanchnic inflow must not exceed portal venous blood flow in patients with recanalized para-umbilical veins. Portal vein velocity and portal venous blood flow measurements alone are not useful parameters for discriminating patients with cirrhosis from healthy subjects

Superior Mesenteric Artery Blood Flow Modifications During Off-Pump Coronary Surgery

2006 ◽  
Vol 82 (1) ◽  
pp. 62-67 ◽  
Author(s):  
Giuseppe Fiore ◽  
Nicola Brienza ◽  
Pasquale Cicala ◽  
Pasquale Tunzi ◽  
Nicola Marraudino ◽  
...  
Keyword(s):  
Blood Flow ◽  
Superior Mesenteric Artery ◽  
Mesenteric Artery ◽  
Coronary Surgery ◽  
Artery Blood Flow ◽  
Off Pump ◽  
Mesenteric Artery Blood Flow

Hemodynamic responses to glycols and to hemolysis

1969 ◽  
Vol 47 (6) ◽  
pp. 563-569 ◽  
Author(s):  
Keith MacCannell
Keyword(s):  
Blood Flow ◽  
Superior Mesenteric Artery ◽  
Renal Blood Flow ◽  
Mesenteric Artery ◽  
Direct Injection ◽  
Artery Blood Flow ◽  
Passive Response ◽  
Flow Through ◽  
Vascular Beds ◽  
Mesenteric Artery Blood Flow

Ethylene and propylene glycol both decrease renal blood flow in dogs while increasing flow through the superior mesenteric artery. The decrease in renal blood flow is not a passive response to dilatation of major vascular beds since it precedes the increment in superior mesenteric arterial flow and since it can be duplicated by direct injection of glycols into the renal artery. These rheological changes in response to glycols are at least partly due to hemolysis since intravenous injection of plasma from hemolyzed blood or of crystalline hemoglobin produces the same pattern of response, which is not blocked by phenoxybenzamine. However, the production of hemoglobinemia may not be the sole explanation for the vascular responses to the glycols, since a concentration of 2 %, which does not induce detectable hemolysis, still produces the characteristic increase in superior mesenteric artery blood flow.

Sign in / Sign up

Export Citation Format

Share Document