Cytokine polymorphisms and nephrotic syndrome

2002 ◽  
Vol 102 (5) ◽  
pp. 513 ◽  
Author(s):  
PETER W. MATHIESON
Keyword(s):  
Nephrotic Syndrome

Hereditary nephritis with the nephrotic syndrome

1970 ◽  
Vol 125 (3) ◽  
pp. 459-461 ◽  
Author(s):  
J. H. Felts
Keyword(s):  
Nephrotic Syndrome ◽  
Hereditary Nephritis

Nephrotic syndrome. A hypercoagulable state

1971 ◽  
Vol 127 (6) ◽  
pp. 1021-1027 ◽  
Author(s):  
A. G. Kendall
Keyword(s):  
Nephrotic Syndrome ◽  
Hypercoagulable State

Nephrotic syndrome with use of ammoniated mercury

1967 ◽  
Vol 120 (5) ◽  
pp. 581-586 ◽  
Author(s):  
D. S. Silverberg
Keyword(s):  
Nephrotic Syndrome

ITI with high-dose FIX and combined immunosuppressive therapy in a patient with severe haemophilia B and inhibitor

2009 ◽  
Vol 29 (02) ◽  
pp. 155-157 ◽  
Author(s):  
H. Hauch ◽  
J. Rischewski ◽  
U. Kordes ◽  
J. Schneppenheim ◽  
R. Schneppenheim ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Immunosuppressive Agents ◽  
Tolerance Induction ◽  
Intravenous Immunoglobulins ◽  
Factor Ix ◽  
High Dose ◽  
Allergic Reactions ◽  
Success Rates ◽  
Serious Infections ◽  
History Of

SummaryInhibitor development is a rare but serious event in hemophilia B patients. Management is hampered by the frequent occurrence of allergic reactions to factor IX, low success rates of current inhibitor elimination protocols and the risk of development of nephrotic syndrome. Single cases of immune tolerance induction (ITI) including immunosuppressive agents like mycophenolat mofetil (MMF) or rituximab have been reported. We present a case of successful inhibitor elimination with a combined immune-modulating therapy and high-dose factor IX (FIX). This boy had developed a FIX inhibitor at the age of 5 years and had a history of allergic reactions to FIX and to FEIBA→. Under on-demand treatment with recombinant activated FVII the inhibitor became undetectable but the boy suffered from multiple joint and muscle bleeds. At the age of 11.5 years ITI was attempted with a combination of rituximab, MMF, dexamethasone, intravenous immunoglobulins and high-dose FIX. The inhibitor did not reappear and FIX half-life normalized. No allergic reaction, no signs of nephrotic syndrome and no serious infections were observed.

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