idiopathic nephrotic syndrome
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Author(s):  
Clara Cébron ◽  
Astrid Godron-Dubrasquet ◽  
Nathalie Aladjidi ◽  
Gwenaelle Roussey ◽  
Olivia Boyer ◽  
...  

2022 ◽  
Vol 141 ◽  
pp. 21-32
Author(s):  
Noha Rabie Bayomy ◽  
Wafaa Moustafa Abo Alfottoh ◽  
Shaimaa Ahmed Ali Eldeep ◽  
Asmaa Mohamed Salah Ibrahim Mabrouk Mersal ◽  
Hamed Mohamed Amer Abd El- Bary ◽  
...  

Author(s):  
Luiz Figueira Pinto

Nephrotic syndrome is a chronic clinical condition and drugs used in its treatment may result in severe side-effects. Renal transplantation or renal ablation and subsequent chronic dialysis treatment may be the only feasible way to patients. The present article reports the case of a 23-years-old white woman that presented nephrotic syndrome and was successfully treated with homeopathic medicines. Six kind of homeopathic diagnoses were made to build the clinical homeopathic picture of the patient and to determine the appropriate medicines, according to the clinical protocol used. Apis mellifica was the main medicine used to treat the diathesis sycosis. The satisfactory treatment outcome shows that the judicious homeopathic therapeutic may be a valuable resource in the treatment of nephrotic syndrome. Keywords: Nephrotic syndrome; Clinical protocol; Diathesis; Sycosis; Homeopathy   Um caso de síndrome nefrótica idiopática tratada com terapéutica homeopática. Resumo A síndrome nefrótica é uma condição clínica crônica. Os fármacos utilizados em seu tratamento podem produzir severos efeitos colaterais. O transplante ou a ablação renal, com a necessidade posterior de diálise, as vezes é a única alternativa real de tratamento. Este artigo descreve o caso de um paciente de 23 anos de idade portador de síndrome nefrótica. Foram realizados 6 diagnósticos homeopáticos para construir um quadro clínico homeopático do paciente e determinar os medicamentos homeopáticos, bem como o protocolo terapéutico. Apis mellifica foi o principal medicamento utilizado para tratar a diástesis sicótica. Os resultados terapéuticos foram satisfatórios e indicam que uma terapéutica homeopática racional pode ser um valioso recurso no tratamento da síndrome nefrótica. Palavras-chave: Síndrome nefrótica; Protocolo clínico; Diatese; Sicose; Homeopatia.   Un caso de síndrome nefrotico idiopatico tratado con terapeutica homeopatica Resumen El síndrome nefrótico es una condición clínica crónica; los fármacos utilizados en su tratamiento pueden producir severos efectos colaterales. El trasplante o ablación renal, con la necesidad posterior de diálisis, a veces es la única alternativa real de tratamiento. Este artículo describe el caso de una paciente de 23 años de edad portadora de síndrome nefrótico; 6 diagnósticos homeopáticos fueron realizados para construir el cuadro clínico homeopático de la paciente y determinar los medicamentos homeopáticos, como prescripto por el protocolo terapéutico utilizado. Apis mellifica fue el principal medicamento utilizado para tratar la diátesis sicótica. Los resultados terapéuticos favorables muestran que una terapéutica homeopática racional puede ser un recurso valioso en el tratamiento del síndrome nefrótico. Palabras-clave: Síndrome nefrótico; Protocolo clínico; Diatese; Sicose; Homeopatia   Correspondence author: Luiz Figueira Pinto, [email protected] How to cite this article: Pinto LF. A case of idiopathic nephrotic syndrome treated with the homeopathic therapeutic. Int J High Dilution Res [online]. 2009 [cited YYYY Mmm dd]; 8(26):26-32. Available from: http://journal.giri-society.org/index.php/ijhdr/article/view/302/382.  


Author(s):  
Aliou Abdoulaye Ndongo ◽  
Djibril Boiro ◽  
Idrissa Basse ◽  
Younoussa Kéita ◽  
Ndiogou Seck ◽  
...  

Background and Aim: Idiopathic nephrotic syndrome or nephrosis causes massive protein leakage in the urine. Its treatment requires steroids (prednisone, methylprednisolone), often for a prolonged period, notably in case of steroid-dependence or steroid-resistance. In children, long-term use of steroids can lead to several side effects such as statural growth retardation/ stunting. This study evaluated the frequency of stunting in idiopathic nephrotic syndrome in children on steroids and identified the associated factors.      Material and Methods: This was a retrospective, descriptive cohort study carried out in children aged 0 to 16 years treated at the paediatric nephrology unit of Aristide Le Dantec Hospital in Dakar, between 1 December 2017 and 31 May 2020. All records of nephrotic children treated in outpatient or inpatient setting were included. These children had to be on corticosteroid therapy for at least 30 months and have a height taken regularly during follow-up consultations. Results: Of 259 children followed for idiopathic nephrotic syndrome, 93 were included in the study. The median age was 96.5 months and the sex ratio was 1.9. The mean height of the children at the beginning of the follow-up was -0.26 DS, at the end it was -0.88 DS. At the beginning of the follow-up, 8 children had already stunting. At 12 months follow-up, 72 children (77.4%) had a decrease in z-score; and at 30 months, there were 7 more children (84.9%) who had a decrease in z-score. Methylprednisolone boluses were given to 17 children (18.3%). Calcium supplementation was done in 91 children (97.8%). Vitamin D supplementation was given to 91 children (97.8%). The mean number of relapses was 1.8. Factors associated with stunting were number of relapses ≤3 (p=0.03), duration of corticosteroid therapy >6 months (p<0.0001) and cumulative doses of prednisone >100 mg/kg (p=0.04). Conclusion: In prolonged nephrotic syndrome in children, corticosteroids can cause stunting.


Author(s):  
S. L. Morozov ◽  
V. V. Dlin

Idiopathic nephrotic syndrome is the most common glomerulopathy in children, with a prevalence of approximately 16 per 100,000 of child population worldwide. Any chronic glomerular disease has the same type of development mechanism. Regardless of the damaging factor, after the death of a significant part of the nephrons, there occurs a steady decrease in the glomerular filtration rate, while morphologically we most often determine focal segmental glomerulosclerosis. Studying the causes of focal segmental glomerulosclerosis is an urgent problem in pediatric nephrology. Recently, there has been discussed the role of the cation channels of the potential receptor TRPC of podocytes in the development of proteinuria and focal segmental glomerulosclerosis. The article provides data on the role of TRPC receptors in the pathogenesis of focal segmental glomerulosclerosis. The authors present their our own data demonstrating gene expression of the cationic channels family of the potential receptor TRPC1, TRPC3, TRPC4, TRPC5 and TRPC6 in children with idiopathic nephrotic syndrome, depending on the morphological picture of the disease and sensitivity to steroid therapy.


2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Agnes Hackl ◽  
Seif El Din Abo Zed ◽  
Paul Diefenhardt ◽  
Julia Binz-Lotter ◽  
Rasmus Ehren ◽  
...  

AbstractIdiopathic nephrotic syndrome (INS) in children is characterized by massive proteinuria and hypoalbuminemia and usually responds well to steroids. However, relapses are frequent, which can require multi-drug therapy with deleterious long-term side effects. In the last decades, different hypotheses on molecular mechanisms underlying INS have been proposed and several lines of evidences strongly indicate a crucial role of the immune system in the pathogenesis of non-genetic INS. INS is traditionally considered a T-cell-mediated disorder triggered by a circulating factor, which causes the impairment of the glomerular filtration barrier and subsequent proteinuria. Additionally, the imbalance between Th17/Tregs as well as Th2/Th1 has been implicated in the pathomechanism of INS. Interestingly, B-cells have gained attention, since rituximab, an anti-CD20 antibody demonstrated a good therapeutic response in the treatment of INS. Finally, recent findings indicate that even podocytes can act as antigen-presenting cells under inflammatory stimuli and play a direct role in activating cellular pathways that cause proteinuria. Even though our knowledge on the underlying mechanisms of INS is still incomplete, it became clear that instead of a traditionally implicated cell subset or one particular molecule as a causative factor for INS, a multi-step control system including soluble factors, immune cells, and podocytes is necessary to prevent the occurrence of INS. This present review aims to provide an overview of the current knowledge on this topic, since advances in our understanding of the immunopathogenesis of INS may help drive new tailored therapeutic approaches forward.


Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 4110
Author(s):  
Turolo Stefano ◽  
Edefonti Alberto ◽  
Morello William ◽  
Bolzan Giulia ◽  
Syren M. Louise ◽  
...  

The fatty acid profiles of patients with idiopathic nephrotic syndrome (INS) are different from that of healthy controls, even during remission, revealing an increase of the pro-inflammatory omega 6 series. It is still unknown whether the concomitance of nephrotic syndrome affects the potential positive effects of the Mediterranean diet on the levels of omega 3 and 6 fatty acids. We performed a cross-sectional study to evaluate the association between the adherence to the Mediterranean diet and fatty acid profile in 54 children with INS. The dietary habits were assessed through the validated Kidmed questionnaire. Patients with higher adherence had lower levels of linoleic acid and total omega-6. Moreover, a negative correlation between proteinuria and the anti-inflammatory omega-3 series was found. In conclusion, patients with INS with proteinuria and low adherence to the Mediterranean diet have an imbalance in the omega-6/omega-3 ratio that may benefit from following the Mediterranean diet.


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