The role of antidiuretic hormone in cold‐induced diuresis in the anaesthetized rat

1998 ◽  
Vol 162 (4) ◽  
pp. 475-480 ◽  
Author(s):  
BROMAN ◽  
KÄLLSKOG ◽  
NYGREN ◽  
WOLGAST
Keyword(s):  
Antidiuretic Hormone ◽  
Anaesthetized Rat

Effects of vasopressin administration on diuresis of water immersion in normal humans

1981 ◽  
Vol 51 (6) ◽  
pp. 1384-1387 ◽  
Author(s):  
M. Epstein ◽  
A. G. DeNunzio ◽  
R. D. Loutzenhiser
Keyword(s):  
Antidiuretic Hormone ◽  
Flow Rate ◽  
Water Immersion ◽  
Normal Subjects ◽  
Urinary Flow Rate ◽  
Urinary Flow ◽  
Relative Role ◽  
Normal Humans

Although previous studies have demonstrated that water immersion to the neck (NI) results in a significant diuresis, the mechanisms are incompletely delineated. Because recent studies in our laboratory have demonstrated that NI is associated with a suppression of antidiuretic hormone (ADH), it is possible that such a suppression mediates the encountered diuresis. The present study was undertaken to assess more directly the relative role of ADH suppression by determining the effects of vasopressin administration. Six hydrated normal subjects were studied on two occasions while undergoing 6 h of NI. During the second NI study, aqueous vasopressin (20 mU/h) was infused for the initial 4 h of study (NI + vasopressin). NI resulted in a significant increase in urinary flow rate beginning during hour 1 and persisting throughout NI. In contrast, during NI + vasopressin, the anticipated diuresis was abolished throughout the 4 h of vasopressin administration. Cessation of vasopressin administration during the final 2 h of NI + vasopressin resulted in a marked and prompt diuresis. The present observations are consistent with the formulation that ADH suppression participates importantly in mediating the diuresis of NI in hydrated normal subjects.

Vascular volume and blood level of antidiuretic hormone

1962 ◽  
Vol 202 (4) ◽  
pp. 791-794 ◽  
Author(s):  
Leonard Share
Keyword(s):  
Antidiuretic Hormone ◽  
Blood Level ◽  
Peritoneal Lavage ◽  
Extracellular Fluid ◽  
Hypertonic Solution ◽  
Vascular Volume ◽  
Fourfold Increase ◽  
Chemical Procedure ◽  
Dextran Solution

The role of vascular volume in regulation of the blood level of antidiuretic hormone (ADH) was investigated utilizing a chemical procedure for extraction, isolation, and concentration of ADH in blood. The antidiuretic material recovered from blood was identified as ADH on the basis of its biological activity and the results of a number of chemical tests. Reduction in extracellular fluid volume by peritoneal lavage with hypertonic solution produced a fourfold increase in the blood titer of ADH within 20 min. Expansion of vascular volume at that time by the intravenous infusion of isotonic dextran solution resulted in a 50% reduction in the blood level of ADH. This reduction was maintained for the 30-min period of observation, although the blood level of ADH rose progressively when the lavage procedure was uninterrupted by infusion of dextran solution. It is concluded that blood volume is an important factor in regulation of blood concentration of ADH.

Role of Antidiuretic Hormone in Impaired Urinary Dilution Associated with Chronic Bile-Duct Ligation

1980 ◽  
Vol 58 (6) ◽  
pp. 493-500 ◽  
Author(s):  
O. S. Better ◽  
G. A. Aisenbrey ◽  
T. Berl ◽  
R. J. Anderson ◽  
W. A. Handelman ◽  
...  
Keyword(s):  
Bile Duct ◽  
Antidiuretic Hormone ◽  
Bile Duct Ligation ◽  
Diluting Segment ◽  
Water Excretion ◽  
Duct Ligation ◽  
Normal Mean ◽  
And Function ◽  
Distal Delivery

1. The effect of chronic bile-duct ligation on systemic and renal haemodynamics and on the capacity to dilute the urine was studied in conscious rats. Sham-operated rats served as controls. 2. In the rats with bile-duct ligation, the maximal urinary diluting capacity was impaired, despite an expanded plasma volume, a normal mean arterial pressure and cardiac output, and normal intrarenal determinants of water excretion including distal delivery of fluid and function of the diluting segment. 3. In contrast, maximal urinary dilution capacity was intact in rats with congenital central diabetes insipidus and chronic bile-duct ligation. 4. It is concluded that the defect in urinary dilution in rats with chronic bile-duct ligation is dependent on antidiuretic hormone.

scholarly journals The respiratory role of the ventral surface of the medulla studied in the anaesthetized rat.

1980 ◽  
Vol 307 (1) ◽  
pp. 503-515 ◽  
Author(s):  
J L Malcolm ◽  
I H Sarelius ◽  
J D Sinclair
Keyword(s):  
Ventral Surface ◽  
Anaesthetized Rat

scholarly journals Role of Antidiuretic Hormone in Hyponatremia in Patients with Isolated Adrenocorticotropic Hormone Deficiency.

1991 ◽  
Vol 38 (3) ◽  
pp. 325-330 ◽  
Author(s):  
SAN-E ISHIKAWA ◽  
GENRO FUJISAWA ◽  
YASUSHI TSUBOI ◽  
KOJI OKADA ◽  
TAKESHI KUZUYA ◽  
...  
Keyword(s):  
Antidiuretic Hormone ◽  
Adrenocorticotropic Hormone ◽  
Hormone Deficiency ◽  
Isolated Adrenocorticotropic Hormone Deficiency
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