A cytotoxic T lymphocyte antigen-4 (CTLA-4) gene polymorphism is associated with autoimmune Addison's disease in English patients

1998 ◽  
Vol 49 (5) ◽  
pp. 609-613 ◽  
Author(s):  
Kemp ◽  
Ajjan ◽  
Husebye ◽  
Peterson ◽  
Uibo ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Addison’S Disease ◽  
Addison's Disease ◽  
Lymphocyte Antigen

scholarly journals Polymorphisms in the Cytotoxic T Lymphocyte Antigen-4 Gene Region Confer Susceptibility to Addison’s Disease

2004 ◽  
Vol 89 (7) ◽  
pp. 3474-3476 ◽  
Author(s):  
Anne Blomhoff ◽  
Benedicte A. Lie ◽  
Anne G. Myhre ◽  
E. Helen Kemp ◽  
Anthony P. Weetman ◽  
...  
Keyword(s):  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Adaptive Immune System ◽  
Addison’S Disease ◽  
Addison's Disease ◽  
Endocrine Disorders ◽  
Gene Splicing ◽  
Lymphocyte Antigen ◽  
Autoimmune Thyroid ◽  
Activated T Lymphocytes

Abstract The cytotoxic T lymphocyte antigen-4 (CTLA4) gene on chromosome 2q33 encodes a key regulator in the adaptive immune system. The CTLA4 surface molecule is expressed on activated T lymphocytes and involved in down-regulation of the immune response. Previous studies on a possible association between autoimmune Addison’s disease and CTLA4 polymorphisms have shown conflicting results. A recent study identified new candidate polymorphisms in the CTLA4 region, influencing gene splicing and thereby the relative abundance of soluble CTLA4. We genotyped 134 patients with Addison’s disease and 413 healthy controls from Norway and United Kingdom for these newly identified polymorphisms. Our data demonstrate that the same polymorphisms that have recently been demonstrated to confer susceptibility to autoimmune thyroid disease and type 1 diabetes also confer susceptibility to Addison’s disease. This finding suggests that polymorphisms in CTLA4 confer general risk to develop autoimmunity and identifies a potential therapeutic target in the prevention of autoimmune endocrine disorders.

Association of cytotoxic T-lymphocyte antigen 4 +49A/G gene polymorphism with acute rejection risk in renal transplantation

2017 ◽  
Vol 21 (4) ◽  
pp. e12916 ◽  
Author(s):  
Chun-Hua Yang ◽  
Xue-Xia Chen ◽  
Li Chen ◽  
Dong-Hua Zheng ◽  
Qiong-Shan Liu ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Acute Rejection ◽  
Gene Polymorphism ◽  
T Lymphocyte ◽  
Cytotoxic T Lymphocyte ◽  
Lymphocyte Antigen
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