scholarly journals Deoxycholic acid treatment in patients with cholesterol gallstones: failure to detect a suppression of cholesterol 7alpha-hydroxylase activity

1999 ◽  
Vol 246 (4) ◽  
pp. 399-407 ◽  
Author(s):  
C.-G. Hillebrant ◽  
B. Nyberg ◽  
B. Angelin ◽  
M. Axelson ◽  
I. Bjorkhem ◽  
...  
2019 ◽  
Vol 21 (6) ◽  
pp. 571-572 ◽  
Author(s):  
Deshan Frank Sebaratnam ◽  
Xin Lin Wong ◽  
Leo Kim ◽  
Karen Cheung

Author(s):  
Flavio Lirussi ◽  
Rosa Maria Iemmolo ◽  
Rocco Orlando ◽  
Gino Nassuato ◽  
Maurizio Muraca ◽  
...  

2020 ◽  
Vol 6 (3) ◽  
pp. 232
Author(s):  
James T. Pathoulas ◽  
Addison M. Demer ◽  
Jaime L. Kingsley-Loso ◽  
Ronda S. Farah

2018 ◽  
Vol 154 (6) ◽  
pp. 735 ◽  
Author(s):  
Michael A. Cardis ◽  
Cynthia Marie Carver DeKlotz

Author(s):  
T. Kanetaka ◽  
M. Cho ◽  
S. Kawamura ◽  
T. Sado ◽  
K. Hara

The authors have investigated the dissolution process of human cholesterol gallstones using a scanning electron microscope(SEM). This study was carried out by comparing control gallstones incubated in beagle bile with gallstones obtained from patients who were treated with chenodeoxycholic acid(CDCA).The cholesterol gallstones for this study were obtained from 14 patients. Three control patients were treated without CDCA and eleven patients were treated with CDCA 300-600 mg/day for periods ranging from four to twenty five months. It was confirmed through chemical analysis that these gallstones contained more than 80% cholesterol in both the outer surface and the core.The specimen were obtained from the outer surface and the core of the gallstones. Each specimen was attached to alminum sheet and coated with carbon to 100Å thickness. The SEM observation was made by Hitachi S-550 with 20 kV acceleration voltage and with 60-20, 000X magnification.


Author(s):  
George F. Leeper

Polysaccharide elementary fibrils are usually fasciated into microfibrils of from one hundred to a few hundred Angstroms wide. Cellulose microfibrils when subjected to acid treatment dissociate into component elementary fibrils. For pectic acid it was observed that variations in pH could cause a change in the fasciation of the elementary fibrils.Solutions of purified pectic acid and sodium phosphotungtate were adjusted to various pH levels with NaOH or HCl and diluted to give a final concentration of 0.5 and 1% for the polysaccharide and negative stains respectively. Micrographs were made of the samples after drying on a carbon film covered grid. The average number of elementary fibrils was determined by counting the number of elementary fibrils in each fascicle intersected by lines drawn across the micrograph.


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