Protein farnesyltransferase inhibitors interfere with farnesyl diphosphate binding by rubber transferase

Rubber Transferase

A Review on Plasmodium falciparum-Protein Farnesyltransferase Inhibitors as Antimalarial Drug Targets

Current Drug Targets ◽

10.2174/1389450117666160823165004 ◽

2017 ◽

Vol 18 (14) ◽

Cited By ~ 5

Author(s):

Kamlesh Sharma

Keyword(s):

Plasmodium Falciparum ◽

Antimalarial Drug ◽

Drug Targets ◽

Falciparum Protein

Protein Farnesyltransferase Inhibitors

Frontiers in Medicinal Chemistry - Online ◽

10.2174/1567204043396695 ◽

2004 ◽

Vol 1 (1) ◽

pp. 97-128

Author(s):

Semiramis Ayral-Kaloustian ◽

Edward J. Salaski

Keyword(s):

Highly improved antiparasitic activity after introduction of an N-benzylimidazole moiety on protein farnesyltransferase inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2015.12.045 ◽

2016 ◽

Vol 109 ◽

pp. 173-186 ◽

Cited By ~ 11

Author(s):

Damien Bosc ◽

Elisabeth Mouray ◽

Sandrine Cojean ◽

Caio Haddad Franco ◽

Philippe M. Loiseau ◽

...

Keyword(s):

Antiparasitic Activity ◽

New protein farnesyltransferase inhibitors in the 3-arylthiophene 2-carboxylic acid series: diversification of the aryl moiety by solid-phase synthesis

Journal of Enzyme Inhibition and Medicinal Chemistry ◽

10.3109/14756366.2011.643302 ◽

2012 ◽

Vol 28 (1) ◽

pp. 163-171 ◽

Cited By ~ 25

Author(s):

Sébastien Lethu ◽

Damien Bosc ◽

Elisabeth Mouray ◽

Philippe Grellier ◽

Joëlle Dubois

Keyword(s):

Carboxylic Acid ◽

Solid Phase Synthesis ◽

Solid Phase ◽

Phase Synthesis ◽

New Protein

QSAR study on tetrahydroquinoline analogues as plasmodium protein farnesyltransferase inhibitors: A comparison of rationales of malarial and mammalian enzyme inhibitory activities for selectivity

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2008.01.025 ◽

2008 ◽

Vol 43 (12) ◽

pp. 2751-2767 ◽

Cited By ~ 15

Author(s):

Manish K. Gupta ◽

Yenamandra S. Prabhakar

Keyword(s):

Qsar Study ◽

Mammalian Enzyme ◽

Inhibitory Activities

Farnesyl Diphosphate Analogues with Aryl Moieties Are Efficient Alternate Substrates for Protein Farnesyltransferase

Biochemistry ◽

10.1021/bi3011362 ◽

2012 ◽

Vol 51 (41) ◽

pp. 8307-8319 ◽

Cited By ~ 10

Author(s):

Thangaiah Subramanian ◽

June E. Pais ◽

Suxia Liu ◽

Jerry M. Troutman ◽

Yuta Suzuki ◽

...

Keyword(s):

Farnesyl Diphosphate ◽

The effects of protein farnesyltransferase inhibitors on trypanosomatids: inhibition of protein farnesylation and cell growth

Molecular and Biochemical Parasitology ◽

10.1016/s0166-6851(98)00053-x ◽

1998 ◽

Vol 94 (1) ◽

pp. 87-97 ◽

Cited By ~ 65

Author(s):

Kohei Yokoyama ◽

Patty Trobridge ◽

Frederick S Buckner ◽

Jeffrey Scholten ◽

Kenneth D Stuart ◽

...

Keyword(s):

Cell Growth ◽

Kurasoins A and B, New Protein Farnesyltransferase Inhibitors Produced by Paecilomyces sp. FO-3684. II. Structure Elucidation and Total Synthesis.

The Journal of Antibiotics ◽

10.7164/antibiotics.49.886 ◽

1996 ◽

Vol 49 (9) ◽

pp. 886-889 ◽

Cited By ~ 29

Author(s):

RYUJI UCHIDA ◽

KAZURO SHIOMI ◽

TOSHIAKI SUNAZUKA ◽

JUNJI INOKOSHI ◽

AI NISHIZAWA ◽

...

Keyword(s):

Total Synthesis ◽

Structure Elucidation ◽

New Protein

Second Generation Tetrahydroquinoline-Based Protein Farnesyltransferase Inhibitors as Antimalarials

Journal of Medicinal Chemistry ◽

10.1021/jm0703340 ◽

2007 ◽

Vol 50 (19) ◽

pp. 4585-4605 ◽

Cited By ~ 39

Author(s):

Pravin Bendale ◽

Srinivas Olepu ◽

Praveen Kumar Suryadevara ◽

Vivek Bulbule ◽

Kasey Rivas ◽

...

Keyword(s):

Second Generation ◽

Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice.

Proceedings of the National Academy of Sciences ◽

10.1073/pnas.91.19.9141 ◽

1994 ◽

Vol 91 (19) ◽

pp. 9141-9145 ◽

Cited By ~ 187

Author(s):

N. E. Kohl ◽

F. R. Wilson ◽

S. D. Mosser ◽

E. Giuliani ◽

S. J. deSolms ◽

...

Keyword(s):

Nude Mice ◽