Delayed Administration Of Jtp-2942, A Novel Thyrotropin-Releasing Hormone Analogue, Improves Cerebral Blood Flow And Metabolism In Rat Postischaemic Brain

2001 ◽  
Vol 28 (1-2) ◽  
pp. 48-54 ◽  
Author(s):  
T Katsumata ◽  
Y Katayama ◽  
H Yonemori ◽  
H Muramatsu ◽  
T Otori ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Thyrotropin Releasing Hormone ◽  
Hormone Analogue ◽  
Releasing Hormone

scholarly journals Effect of Thyrotropin-Releasing Hormone on Cerebral Blood Flow in Conscious Rat

1989 ◽  
Vol 9 (2) ◽  
pp. 196-203 ◽  
Author(s):  
Yasushi Kondoh ◽  
Shigenori Mizusawa ◽  
Matsutaro Murakami ◽  
Ken Nagata ◽  
Hiroshi Sasaki ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
Gray Matter ◽  
Brain Regions ◽  
Thyrotropin Releasing Hormone ◽  
Conscious Rat ◽  
Releasing Hormone ◽  
Conscious Rats ◽  
Prostaglandin Metabolism

The effect of thyrotropin-releasing hormone (TRH) was studied on local CBF (LCBF) in normal conscious rats. LCBF was measured by the autoradiographic [14C]iodoantipyrine method 5 min after TRH (5 mg/kg, i.v.) administration. TRH significantly increased LCBF in 22 of 33 brain regions. This increase of LCBF exceeded 100% of the control values in the cerebral cortices, whereas there was no significant increase in white matter or in some gray matter structures. The increase of CBF following TRH administration was abolished by pretreatment with indomethacin (5 mg/kg, i.v.). The mechanisms underlying the increase of CBF following TRH administration are discussed in relation to prostaglandin metabolism.

Effects of thyrotropin-releasing hormone on regional cerebral blood flow in man

1992 ◽  
Vol 126 (3) ◽  
pp. 243-246 ◽  
Author(s):  
Peter S Oturai ◽  
Lars Friberg ◽  
Ian Sam ◽  
Hans Perrild
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Regional Cerebral Blood Flow ◽  
Single Photon ◽  
Photon Emission ◽  
Thyrotropin Releasing Hormone ◽  
Regional Cerebral Blood ◽  
Double Blind ◽  
Releasing Hormone ◽  
Thalamic Region

To assess the regional changes in cerebral blood flow, 10 healthy volunteers were given 400 μg thyrotropin-releasing hormone iv in a double-blind, randomized, cross-over study. Regional cerebral blood flow was determined simultaneously in two slices of the brain, using a single photon emission computerized tomograph and inhalation of 133Xe. Thyrotropin-releasing hormone caused a significant mean increase of 3.7% (range −8.8–22.7) in blood flow in a region consistent with the left thalamus compared to placebo (3.2% decrease). In 25 other regions no significant change was detected. The thalamic region has previously been shown to be a region especially affected by thyrotropin-releasing hormone in animal studies. The thyrotropin-releasing hormone injection was followed by a minor rise in systemic blood pressure, but not a rise that could affect the cerebral blood flow. The effect of thyrotropin-releasing hormone on the regional cerebral blood flow in the thalamic region was much lower compared to changes found in sedated animals given a hundredfold higher dose of thyrotropin-releasing hormone.

Thyrotropin-releasing hormone in the dorsal vagal complex stimulates pancreatic blood flow in rats

2005 ◽  
Vol 131 (1-3) ◽  
pp. 74-81 ◽  
Author(s):  
Masashi Yoneda ◽  
Manabu Goto ◽  
Kimihide Nakamura ◽  
Shiro Yokohama ◽  
Toru Kono ◽  
...  
Keyword(s):  
Blood Flow ◽  
Thyrotropin Releasing Hormone ◽  
Dorsal Vagal Complex ◽  
Pancreatic Blood Flow ◽  
Releasing Hormone
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