Posttransplant IgA nephropathy: A clinicopathological study in comparison with IgA nephropathy in native kidney

Nephrology ◽  
2000 ◽  
Vol 5 (s1) ◽  
pp. A13-A13
Author(s):  
K Oka ◽  
M Izumi ◽  
T Sugiura ◽  
Y Isaka ◽  
M Takenaka ◽  
...  
2014 ◽  
Vol 466 (1) ◽  
pp. 77-83
Author(s):  
Guido F. Laube ◽  
Ashot Sarkissian ◽  
Helen Nazaryan ◽  
Giuseppina Spartà ◽  
Armen Sanamyan ◽  
...  

Nephrology ◽  
2003 ◽  
Vol 8 (s4) ◽  
pp. A115-A115
Author(s):  
Hiroko CHIKAMOTO ◽  
Motoshi HATTORI ◽  
Shigeru HORITA ◽  
Toshihiro SAWAI ◽  
Tae OHMORI ◽  
...  

2004 ◽  
Vol 124 (sup555) ◽  
pp. 49-53 ◽  
Author(s):  
Shinichi Nishi ◽  
Yuansheng Xie ◽  
Mitsuhiro Ueno ◽  
Naofumi Imai ◽  
Yasushi Suzuki ◽  
...  

1992 ◽  
Vol 5 (1) ◽  
pp. 58-64
Author(s):  
Motoshi Hattori ◽  
Masatoshi Tokuyama ◽  
Yuri Tsunoda ◽  
Yutaka Yamaguchi ◽  
Keiko Ito ◽  
...  

1993 ◽  
Vol 6 (1) ◽  
pp. 62-66
Author(s):  
Mamoru Funai ◽  
Kaname Okada ◽  
Shoji Kagami ◽  
Yuji Morimoto ◽  
Koichiro Kawakami ◽  
...  

2019 ◽  
Vol 49 (1) ◽  
pp. 81-92 ◽  
Author(s):  
Preeti Chandra

Complement activation occurs in many glomerular diseases, the exact pathway(s) of activation has been studied in detail in some diseases but not in all. C4d is generated by the activation of classical and lectin pathways, and its presence can point to the activation of either of these pathways. This review aims to summarize the available data with regard to the deposition of glomerular C4d in native kidney biopsies in different glomerular pathologies that may be useful for future research into the role of complement activation in glomerular diseases. While there is more information on C4d in certain diseases (e.g., Immunoglobulin A (IgA) nephropathy), there is scant data in other diseases (such as focal segmental glomerulosclerosis).


1993 ◽  
Vol 113 (sup508) ◽  
pp. 43-48 ◽  
Author(s):  
Nobuyoshi Sugiyama ◽  
Junko Shimizu ◽  
Masayoshi Nakamura ◽  
Takahiro Kiriu ◽  
Kenichi Matsuoka ◽  
...  

2020 ◽  
Author(s):  
Anri Sawada ◽  
Masayoshi Okumi ◽  
Shigeru Horita ◽  
Tomomi Tamura ◽  
Sekiko Taneda ◽  
...  

Abstract BackgroundMonoclonal tubular basement membrane immune deposits (TBMID) are identified by renal biopsy and are associated with progression of interstitial injury in renal allograft. However, the significance of TBMID in the native kidney remains unclear.MethodWe retrospectively analyzed 3,126 native kidney biopsies and 1,724 zero-hour biopsies performed between 2008 and 2018 in our institution.ResultsThe rate of immunoglobulin G (IgG) TBMID was found to be 5.2 % among native kidney biopsies and 0.4 % among zero-hour biopsies. The rate of IgG TBMID was relatively common in the case of diabetic nephropathy (31.3%) and lupus nephritis (25.5%), but rare in IgA nephropathy (IgAN) (1.1%). Monoclonal IgG TBMID was identified in seven cases, including three zero-hour biopsies. The pathological diagnosis from native kidney biopsy was IgAN in two cases, antineutrophil cytoplasmic antibody-related vasculitis in one, and Focal segmental glomerulosclerosis in one. Zero-hour biopsy revealed IgAN in one case and mild atherosclerosis in two. The combination of IgG1κ was observed in two cases, IgG1λ in three, and IgG2κ in two. Interstitial injury is not severe in all cases. Electron microscopy revealed powdery electron-dense deposits. Monoclonal gammopathy of undetermined significance was diagnosed in one case with IgA nephropathy. Although One patient developed renal failure, all others exhibited stable renal function.ConclusionMonoclonal IgG TBMID in the native kidney is not associated with renal prognosis or interstitial injury. However, this could be a useful immunopathological parameter for early identification of cases requiring hematological investigation and microscopic evaluation.


Nephrology ◽  
1997 ◽  
Vol 3 (s2) ◽  
pp. s701-s707 ◽  
Author(s):  
Hisaki SHIMADA ◽  
Naofumi IMAI ◽  
Yoshikazu MIYAKAWA ◽  
Tukasa NAKAMARU ◽  
Ryo KARASAWA ◽  
...  

1993 ◽  
Vol 96 (8) ◽  
pp. 1264-1269,1389
Author(s):  
KEN-ICHI KOICHI ◽  
SEIICHI YAMAJI ◽  
TAKASI KIMURA ◽  
TOMOHIRO YOSIZAWA ◽  
HITOSI TUJIE

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