Increased Activation of L-Type Voltage-Dependent Calcium Channels Is Associated with Glycine Enhancement of N-Methyl-d-Aspartate-Stimulated Dopamine Release in Global Cerebral Ischemia/Reperfusion

2002 ◽  
Vol 63 (1) ◽  
pp. 215-221 ◽  
Author(s):  
Linda L. Werling ◽  
Paul J. Hoehner ◽  
K. Joseph Hurt ◽  
Laura G. Fox ◽  
Thomas J. J. Blanck ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Calcium Channels ◽  
Dopamine Release ◽  
Ischemia Reperfusion ◽  
Global Cerebral Ischemia ◽  
Cerebral Ischemia Reperfusion ◽  
Voltage Dependent ◽  
Voltage Dependent Calcium Channels

Dopamine release from canine striatum following global cerebral ischemia/reperfusion

1993 ◽  
Vol 606 (1) ◽  
pp. 99-105 ◽  
Author(s):  
Linda L. Werling ◽  
Henry M. Jacocks ◽  
Robert E. Rosenthal ◽  
Gary Fiskum
Keyword(s):  
Cerebral Ischemia ◽  
Dopamine Release ◽  
Ischemia Reperfusion ◽  
Global Cerebral Ischemia ◽  
Cerebral Ischemia Reperfusion

Neuroprotective Effects of Alisol A 24-acetate on Cerebral Ischemia-reperfusion Injury by Regulating PI3K/AKT Pathway

2021 ◽  
Author(s):  
Taotao Lu ◽  
Huihong Li ◽  
Yangjie Zhou ◽  
Wei Wei ◽  
Linlin Ding ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Ischemia Reperfusion Injury ◽  
Neuroprotective Effect ◽  
Ischemia Reperfusion ◽  
Brain Regions ◽  
Global Cerebral Ischemia ◽  
Akt Pathway ◽  
Object Recognition Test ◽  
Neuroprotective Effects ◽  
Cerebral Ischemia Reperfusion

Abstract BackgroundNeuroinflammation and apoptosis are involved in the pathogenesis of ischemic stroke. Alisol A 24-acetate (24A) has a strong inhibitory effect on inflammation and cell apoptosis. The neuroprotective effect of 24A in the global cerebral ischemia/ reperfusion (GCI/R) is still unclear. Methods GCI/R mice was used to investigated the neuroprotective effect of 24A. Modified neurological deficit scores, Morris Water Maze and object recognition test were used to evaluate behaviors. The metabolism in brain regions was detected by MRS. The changes of microglia, astrocytes and neurons was detected. The inflammation and apoptosis were measured.Results The results showed that 24A improved behavioral dysfunction and brain metabolism, alleviate neuroinflammation and apoptosis, inhibited microglia and astrocytes activation, which is associated with the activation of PI3K/AKT pathway. ConclusionsTaken together, our study demonstrated that 24A could alleviate GCI/R injury through anti-neuroinflammation and anti-apoptosis via regulating the PI3K/AKT pathway.

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