scholarly journals In Vivo Effects of Adenosine A1 Receptor Agonist and Antagonist on Neuronal and Astrocytic Intermediary Metabolism Studied with Ex Vivo 13C NMR Spectroscopy

2001 ◽  
Vol 74 (1) ◽  
pp. 327-333 ◽  
Author(s):  
Asta Håberg ◽  
Hong Qu ◽  
Olav Haraldseth ◽  
Geirmund Unsgård ◽  
Ursula Sonnewald
Keyword(s):  
Nmr Spectroscopy ◽  
13C Nmr ◽  
Receptor Agonist ◽  
Ex Vivo ◽  
13C Nmr Spectroscopy ◽  
Adenosine A1 ◽  
Agonist And Antagonist ◽  
A1 Receptor ◽  
In Vivo Effects

scholarly journals NEW PHARMACOLOGICALLY ACTIVE COMPOUNDS BASED ON 5-HYDROXY-7-METHOXY-2-PHENYLCHROMAN-4-ONE

2021 ◽  
Vol 3 ◽  
pp. 119-127
Author(s):  
G.M. Baisarov ◽  
◽  
S.M. Adekenov ◽  
Keyword(s):  
Nmr Spectroscopy ◽  
13C Nmr ◽  
Potassium Carbonate ◽  
13C Nmr Spectroscopy ◽  
1H And 13C Nmr ◽  
Pharmacologically Active ◽  
Pharmacologically Active Compounds ◽  
First Time

The reaction of 5-hydroxy-7-methoxy-2-phenylchroman-4-one with dibromoalkanes in acetone in the presence of potassium carbonate proceeds according to the Michael’s retro-reaction O-alkylation and leads to the formation of the corresponding 2-(bromo-alkoxy) chalcones. The structure of the synthesized compounds was confirmed by IR-, 1H- and 13C-NMR spectroscopy. The cytotoxic, hepatoprotective and anti-inflammatory effects of chalcone derivatives (2-3) were studied for the first time in vitro and in vivo.

Cerebral glucose metabolism and the glutamine cycle as detected by in vivo and in vitro 13C NMR spectroscopy

2004 ◽  
Vol 45 (2-3) ◽  
pp. 297-303 ◽  
Author(s):  
Marı́a A Garcı́a-Espinosa ◽  
Tiago B Rodrigues ◽  
Alejandra Sierra ◽  
Marina Benito ◽  
Carla Fonseca ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Glucose Metabolism ◽  
13C Nmr ◽  
13C Nmr Spectroscopy ◽  
Cerebral Glucose Metabolism

Adenosine attenuation of catecholamine-enhanced contractility of rat heart in vivo

1991 ◽  
Vol 260 (5) ◽  
pp. H1635-H1639 ◽  
Author(s):  
F. D. Romano ◽  
T. S. Naimi ◽  
J. G. Dobson
Keyword(s):  
Rat Heart ◽  
Receptor Agonist ◽  
Jugular Vein ◽  
Cardiac Contractility ◽  
Physiological Role ◽  
Inotropic Effects ◽  
Adenosine A1 ◽  
Positive Inotropic Effects ◽  
A1 Receptor

The antiadrenergic action of adenosine was examined in open- and closed-chest preparations of anesthetized rats. The positive inotropic effects of a jugular vein infusion of either isoproterenol or epinephrine were attenuated by phenylisopropyladenosine, an adenosine A1-receptor agonist. 1,3-Dipropyl,8-cyclopentylxanthine, a specific A1-receptor antagonist, inhibited the action of phenylisopropyladenosine. The results indicate that adenosine receptor-mediated mechanisms are functional in the blood-perfused rodent heart and support the possibility of a physiological role for adenosine in modulating cardiac contractility.

scholarly journals Chronic adenosine A1 receptor agonist and antagonist: effect on receptor density and induced seizures in mice

1994 ◽  
Vol 253 (1-2) ◽  
pp. 95-99 ◽  
Author(s):  
Dag K.J.E. Von Lubitz ◽  
Ian A. Paul ◽  
Xiao-duo Ji ◽  
Margaret Carter ◽  
Kenneth A. Jacobson
Keyword(s):  
Receptor Agonist ◽  
Adenosine A1 Receptor ◽  
Receptor Density ◽  
Adenosine A1 ◽  
Agonist And Antagonist ◽  
A1 Receptor ◽  
Antagonist Effect

Repeated treatment with adenosine A1 receptor agonist and antagonist modifies the anticonvulsant properties of CPPene

1996 ◽  
Vol 317 (2-3) ◽  
pp. 239-245 ◽  
Author(s):  
Giovambattista De Sarro ◽  
Eugenio Donato Di Paola ◽  
Umberto Falconi ◽  
Guido Ferreri ◽  
Angela De Sarro
Keyword(s):  
Receptor Agonist ◽  
Adenosine A1 Receptor ◽  
Repeated Treatment ◽  
Adenosine A1 ◽  
Agonist And Antagonist ◽  
A1 Receptor
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