scholarly journals The Total Amount of DNA Damage Determines Ultraviolet-radiation-induced Cytotoxicity After Uniformor Localized Irradiation of Human Cells

2002 ◽  
Vol 119 (5) ◽  
pp. 1177-1182 ◽  
Author(s):  
Kyoko Imoto ◽  
Nobuhiko Kobayashi ◽  
Sachiko Katsumi ◽  
Yoko Nishiwaki ◽  
Taka-aki Iwamoto ◽  
...  
Keyword(s):  
Dna Damage ◽  
Ultraviolet Radiation ◽  
Human Cells ◽  
Radiation Induced

scholarly journals Sunscreen applied at ≥ 2 mg cm −2 during a sunny holiday prevents erythema, a biomarker of ultraviolet radiation‐induced DNA damage and suppression of acquired immunity

2018 ◽  
Vol 180 (3) ◽  
pp. 604-614 ◽  
Author(s):  
J. Narbutt ◽  
P.A. Philipsen ◽  
G.I. Harrison ◽  
K.A. Morgan ◽  
K.P. Lawrence ◽  
...  
Keyword(s):  
Dna Damage ◽  
Ultraviolet Radiation ◽  
Acquired Immunity ◽  
Radiation Induced

scholarly journals Publisher Correction: Ultraviolet radiation–induced DNA damage is prognostic for outcome in melanoma

2018 ◽  
Vol 25 (2) ◽  
pp. 350-350 ◽  
Author(s):  
Lucas D. Trucco ◽  
Piyushkumar A. Mundra ◽  
Kate Hogan ◽  
Pablo Garcia-Martinez ◽  
Amaya Viros ◽  
...  
Keyword(s):  
Dna Damage ◽  
Ultraviolet Radiation ◽  
Radiation Induced

scholarly journals Role of inhibitory CDC2 phosphorylation in radiation-induced G2 arrest in human cells.

1996 ◽  
Vol 134 (4) ◽  
pp. 963-970 ◽  
Author(s):  
P Jin ◽  
Y Gu ◽  
D O Morgan
Keyword(s):  
Dna Damage ◽  
Chromatin Condensation ◽  
S Phase ◽  
Human Cells ◽  
G2 Arrest ◽  
Hela Cell Lines ◽  
Radiation Induced ◽  
G2 Delay ◽  
In Cells

The activity of the mitosis-promoting kinase CDC2-cyclin B is normally suppressed in S phase and G2 by inhibitory phosphorylation at Thr14 and Tyr15. This work explores the possibility that these phosphorylations are responsible for the G2 arrest that occurs in human cells after DNA damage. HeLa cell lines were established in which CDC2AF, a mutant that cannot be phosphorylated at Thr14 and Tyr15, was expressed from a tetracycline-repressible promoter. Expression of CDC2AF did not induce mitotic events in cells arrested at the beginning of S phase with DNA synthesis inhibitors, but induced low levels of premature chromatin condensation in cells progressing through S phase and G2. Expression of CDC2AF greatly reduced the G2 delay that resulted when cells were X-irradiated in S phase. However, a significant G2 delay was still observed and was accompanied by high CDC2-associated kinase activity. Expression of wild-type CDC2, or the related kinase CDK2AF, had no effect on the radiation-induced delay. Thus, inhibitory phosphorylation of CDC2, as well as additional undefined mechanisms, delay mitosis after DNA damage.

Abstract 4197: A DNA damage checkpoint response to unrepaired ultraviolet radiation-induced lesions which is defective in melanoma

2011 ◽  
Author(s):  
Matthew Wigan ◽  
Sandra Pavey ◽  
Kelly Brooks ◽  
Nichole Giles ◽  
Andrew Burgess ◽  
...  
Keyword(s):  
Dna Damage ◽  
Ultraviolet Radiation ◽  
Dna Damage Checkpoint ◽  
Checkpoint Response ◽  
Radiation Induced

scholarly journals α-Melanocyte-stimulating Hormone Protects from Ultraviolet Radiation-induced Apoptosis and DNA Damage

2004 ◽  
Vol 280 (7) ◽  
pp. 5795-5802 ◽  
Author(s):  
Markus Böhm ◽  
Ilka Wolff ◽  
Thomas E. Scholzen ◽  
Samantha J. Robinson ◽  
Eugene Healy ◽  
...  
Keyword(s):  
Dna Damage ◽  
Ultraviolet Radiation ◽  
Melanocyte Stimulating Hormone ◽  
Radiation Induced ◽  
Induced Apoptosis ◽  
Stimulating Hormone

scholarly journals Ultraviolet radiation-induced DNA damage in promoter elements inhibits gene expression

FEBS Letters ◽  
2003 ◽  
Vol 554 (3) ◽  
pp. 427-432 ◽  
Author(s):  
Rita Ghosh ◽  
Ramakumar Tummala ◽  
David L Mitchell
Keyword(s):  
Gene Expression ◽  
Dna Damage ◽  
Ultraviolet Radiation ◽  
Promoter Elements ◽  
Radiation Induced

Identification of Possible Reactive Oxygen Species Involved in Ultraviolet Radiation-Induced Oxidative DNA Damage

1997 ◽  
Vol 23 (7) ◽  
pp. 980-985 ◽  
Author(s):  
Xueshu Zhang ◽  
Barry S Rosenstein ◽  
Yan Wang ◽  
Mark Lebwohl ◽  
Huachen Wei
Keyword(s):  
Reactive Oxygen Species ◽  
Dna Damage ◽  
Ultraviolet Radiation ◽  
Oxidative Dna Damage ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Radiation Induced

scholarly journals Infrared A radiation promotes survival of human melanocytes carrying ultraviolet radiation-induced DNA damage

2016 ◽  
Vol 25 (6) ◽  
pp. 447-452 ◽  
Author(s):  
Susanne Kimeswenger ◽  
Agatha Schwarz ◽  
Dagmar Födinger ◽  
Susanne Müller ◽  
Hubert Pehamberger ◽  
...  
Keyword(s):  
Dna Damage ◽  
Ultraviolet Radiation ◽  
Human Melanocytes ◽  
Radiation Induced

scholarly journals Significant Suppression of CT Radiation-Induced DNA Damage in Normal Human Cells by the PrC-210 Radioprotector

2018 ◽  
Vol 190 (2) ◽  
pp. 133 ◽  
Author(s):  
Frank Jermusek ◽  
Chelsea Benedict ◽  
Emma Dreischmeier ◽  
Michael Brand ◽  
Michael Uder ◽  
...  
Keyword(s):  
Dna Damage ◽  
Human Cells ◽  
Significant Suppression ◽  
Ct Radiation ◽  
Radiation Induced ◽  
Normal Human ◽  
Normal Human Cells
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