Molecular basis for the high-incidence antigens of the Kell blood group system

Transfusion ◽  
1997 ◽  
Vol 37 (11-12) ◽  
pp. 1117-1122 ◽  
Author(s):  
S Lee ◽  
DS Naime ◽  
ME Reid ◽  
CM Redman
Keyword(s):  
Blood Group ◽  
Molecular Basis ◽  
Blood Group System ◽  
Group System ◽  
High Incidence

Molecular basis of the K:6,-7 [Js(a+b−)] phenotype in the Kell blood group system

Transfusion ◽  
2003 ◽  
Vol 35 (10) ◽  
pp. 822-825 ◽  
Author(s):  
S. Lee ◽  
X. Wu ◽  
M. Reid ◽  
C. Redman
Keyword(s):  
Blood Group ◽  
Molecular Basis ◽  
Blood Group System ◽  
Group System

Molecular basis of the rare gene complex, DIVa(C)-, which encodes four low-prevalence antigens in the Rh blood group system

Vox Sanguinis ◽  
2011 ◽  
Vol 102 (2) ◽  
pp. 167-170 ◽  
Author(s):  
C. H. Hipsky ◽  
K. Hue-Roye ◽  
C. Lomas-Francis ◽  
C.-H. Huang ◽  
M. E. Reid
Keyword(s):  
Blood Group ◽  
Molecular Basis ◽  
Blood Group System ◽  
Gene Complex ◽  
Group System ◽  
Rare Gene ◽  
Low Prevalence ◽  
Rh Blood Group

scholarly journals AQP3 Deficiency in Humans and the Molecular Basis of a Novel Blood Group System, GIL

2002 ◽  
Vol 277 (48) ◽  
pp. 45854-45859 ◽  
Author(s):  
Nathalie Roudier ◽  
Pierre Ripoche ◽  
Pierre Gane ◽  
Pierre Yves Le Pennec ◽  
Geoff Daniels ◽  
...  
Keyword(s):  
Blood Group ◽  
Molecular Basis ◽  
Blood Group System ◽  
Group System

Molecular basis of two novel high-prevalence antigens in the Kell blood group system, KALT and KTIM

Transfusion ◽  
2006 ◽  
Vol 46 (8) ◽  
pp. 1323-1327 ◽  
Author(s):  
Soohee Lee ◽  
Asim K. Debnath ◽  
Xu Wu ◽  
Terry Scofield ◽  
Terry George ◽  
...  
Keyword(s):  
Blood Group ◽  
Molecular Basis ◽  
Blood Group System ◽  
Group System ◽  
High Prevalence

scholarly journals Molecular basis for elliptocytosis associated with glycophorin C and D deficiency in the Leach phenotype

Blood ◽  
1991 ◽  
Vol 78 (6) ◽  
pp. 1603-1606 ◽  
Author(s):  
MJ Telen ◽  
C Le Van Kim ◽  
A Chung ◽  
JP Cartron ◽  
Y Colin
Keyword(s):  
Blood Group ◽  
Molecular Basis ◽  
Messenger Rna ◽  
Genetic Basis ◽  
Stop Codon ◽  
Rare Condition ◽  
Blood Group System ◽  
Group System ◽  
Glycophorin C

Abstract Glycophorin C (GPC) and glycophorin D (GPD) are highly glycosylated integral membrane proteins of human erythrocytes encoded by the same gene and associated with expression of Gerbich blood group system antigens. GPC/D deficiency (the Leach phenotype) is a rare condition usually found after identification of Gerbich blood group system antibodies in persons undergoing prenatal or pretransfusion evaluation. In all cases, the Leach phenotype has been associated with elliptocytosis. Characterization of the molecular basis of this phenotype in three previously uninvestigated families has shown that the most common genetic basis of GPC/D deficiency is deletion of exons 3 and 4 of the GPC gene. However, in one family, the Leach phenotype appeared due to a deletion of one nucleotide in exon 3, causing a frameshift mutation in the messenger RNA and premature generation of a stop codon. The GPC and GPD protein sequences are therefore interrupted in the extracellular domain and probably intracellularly degraded.

scholarly journals The Diego System—Steps in the Investigation of a New Blood Group System. Further Studies

Blood ◽  
1957 ◽  
Vol 12 (2) ◽  
pp. 115-122 ◽  
Author(s):  
MIGUEL LAYRISSE ◽  
TULIO ARENDS
Keyword(s):  
Blood Group ◽  
Room Temperature ◽  
Blood System ◽  
Blood Group System ◽  
South American ◽  
Sex Linkage ◽  
Group System ◽  
Negative Results ◽  
High Incidence ◽  
Ph Range

Abstract The distribution of the Diego factor has been studied in various Mongoloid, Caucasian and Negroid populations. In six South American Indian stocks, one Canadian Indian stock and two groups of Asiatic Mongoloids it was present in high incidence. In Caucasians tested, negative results were found. In two groups of Venezuelan Negroes with probable Indian admixture the factor was also present. The Diego antigen was inherited in single dose (heterozygous) in 41 families studied and could be followed through several generations with no sex-linkage. The first samples of anti-Diego serum reacted only in the indirect anti-globulin test to a titer between 1:256 and 1:512. The enzymes papain and trypsin gave no advantage. It is more active at room temperature (25 C. and 37 C.) than at cold temperature (4 C. and 18 C.). The most suitable pH range is from 5.0 to 8.0. The Diego factor can be considered as part of a new blood group system (the Diego system) which could be classified as the tenth firmly established blood system.

scholarly journals Molecular basis of two novel and related high-prevalence antigens in the Kell blood group system, KUCI and KANT, and their serologic and spatial association with K11 and KETI

Transfusion ◽  
2013 ◽  
pp. n/a-n/a ◽  
Author(s):  
Randall W. Velliquette ◽  
Kim Hue-Roye ◽  
Christine Lomas-Francis ◽  
Barbara Gillen ◽  
Jennifer Schierts ◽  
...  
Keyword(s):  
Blood Group ◽  
Molecular Basis ◽  
Spatial Association ◽  
Blood Group System ◽  
Group System ◽  
High Prevalence

scholarly journals Molecular basis of Rh blood group system in the Malaysian population

2015 ◽  
Vol 9 (1) ◽  
pp. 48 ◽  
Author(s):  
RoziHanisa Musa ◽  
NorAsiah Muhamad ◽  
Afifah Hassan ◽  
Yasmin Ayob ◽  
NarazahMohd Yusoff
Keyword(s):  
Blood Group ◽  
Molecular Basis ◽  
Blood Group System ◽  
Group System ◽  
Malaysian Population ◽  
Rh Blood Group
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