Quercetin Enhances Melanogenesis By Increasing the Activity and Synthesis of Tyrosinase in Human Melanoma Cells and in Normal Human Melanocytes

2004 ◽  
Vol 17 (1) ◽  
pp. 66-73 ◽  
Author(s):  
Hidetaka Nagata ◽  
Susumu Takekoshi ◽  
Reiko Takeyama ◽  
Takao Homma ◽  
R. Yoshiyuki Osamura
Keyword(s):  
Melanoma Cells ◽  
Human Melanoma ◽  
Human Melanoma Cells ◽  
Human Melanocytes ◽  
Normal Human

Regulation of pigmentation by substrate elasticity in normal human melanocytes and melanotic MNT1 human melanoma cells

2014 ◽  
Vol 23 (3) ◽  
pp. 172-177 ◽  
Author(s):  
Hyunjung Choi ◽  
Mina Kim ◽  
Song Ih Ahn ◽  
Eun-Gyung Cho ◽  
Tae Ryong Lee ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
Human Melanoma ◽  
Human Melanoma Cells ◽  
Human Melanocytes ◽  
Normal Human ◽  
Substrate Elasticity

Regulation of integrin-mediated adhesion to laminin and collagen in human melanocytes and in non-metastatic and highly metastatic human melanoma cells

1993 ◽  
Vol 54 (2) ◽  
pp. 315-321 ◽  
Author(s):  
Erik H. J. Danen ◽  
Goos N. P. Van Muijen ◽  
Kees F. J. Jansen ◽  
Dirk J. Ruiter ◽  
Elly Van De Wiel-van Kemenade ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
Human Melanoma ◽  
Human Melanoma Cells ◽  
Human Melanocytes

TXM13 human melanoma cells: a novel source for the inhibition kinetics of human tyrosinase and for screening whitening agents

2006 ◽  
Vol 84 (1) ◽  
pp. 112-116 ◽  
Author(s):  
Yong-Doo Park ◽  
So-yeon Kim ◽  
You-Jeong Lyou ◽  
Dong-Youn Lee ◽  
Jun-Mo Yang
Keyword(s):  
Pigment Cell ◽  
Initial Step ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Inhibition Kinetics ◽  
Whitening Agent ◽  
Human Melanoma Cells ◽  
Human Melanocytes ◽  
Long Time ◽  
Human Tyrosinase

Research involving whitening agents requires several steps of experimentation, and the initial step is to test whitening agents with human melanocytes and those with human tyrosinase. Unfortunately, it takes a long time to gather human melanocytes, and these cells have some limitations when it comes to performing experiments, such as their passage difficulties and their cost. In this study, we suggest that the TXM13 human melanoma cells could be a useful cell candidate for studying human tyrosinase inhibition and depigmentation. We applied a tyrosinase inhibitor, such as dithioglycerine (DTGC), to validate the cell line's usefulness, and we tested the effect of DTGC on TXM13 melanogenesis. The results showed that human tyrosinase from TXM13 was appropriate, according to the inhibition kinetics, and that the conspicuous depigmentation of TXM13 occurred after DTGC treatment without downregulating the tyrosinase expression level. When taken together, our findings provide useful information regarding the use of the TXM13 melanoma cells for the development of whitening agents.Key words: TXM13, pigment cell, human tyrosinase, whitening agent.

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