P069 ONTAMALIMAB, A FULLY HUMAN MONOCLONAL ANTIBODY AGAINST MUCOSAL ADDRESSIN CELL ADHESION MOLECULE-1, PROVIDES SUSTAINED EXPOSURE FOLLOWING LONG-TERM TREATMENT IN PATIENTS WITH ULCERATIVE COLITIS

Yi Wang; J.F. Marier; Leila Kheibarshekan; Nastya Kassir; Patrick Martin

doi:10.1053/j.gastro.2019.11.075

P069 ONTAMALIMAB, A FULLY HUMAN MONOCLONAL ANTIBODY AGAINST MUCOSAL ADDRESSIN CELL ADHESION MOLECULE-1, PROVIDES SUSTAINED EXPOSURE FOLLOWING LONG-TERM TREATMENT IN PATIENTS WITH ULCERATIVE COLITIS

Gastroenterology ◽

10.1053/j.gastro.2019.11.075 ◽

2020 ◽

Vol 158 (3) ◽

pp. S18

Author(s):

Yi Wang ◽

J.F. Marier ◽

Leila Kheibarshekan ◽

Nastya Kassir ◽

Patrick Martin

Keyword(s):

Ulcerative Colitis ◽

Monoclonal Antibody ◽

Cell Adhesion ◽

Adhesion Molecule ◽

Cell Adhesion Molecule ◽

Human Monoclonal Antibody ◽

Term Treatment ◽

Long Term Treatment ◽

Cell Adhesion Molecule 1

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Population Pharmacokinetics and Pharmacodynamics of SHP647, a Fully Human Monoclonal Antibody Against Mucosal Addressin Cell Adhesion Molecule-1 (anti-MAdCAM-1), in Patients With Ulcerative Colitis or Crohnʼs Disease

The American Journal of Gastroenterology ◽

10.14309/00000434-201810001-00704 ◽

2018 ◽

Vol 113 (Supplement) ◽

pp. S396-S397

Author(s):

Yi Wang ◽

J. F. Marier ◽

Jean Lavigne ◽

Nastya Kassir ◽

Patrick Martin

Keyword(s):

Ulcerative Colitis ◽

Monoclonal Antibody ◽

Cell Adhesion ◽

Population Pharmacokinetics ◽

Adhesion Molecule ◽

Cell Adhesion Molecule ◽

Human Monoclonal Antibody ◽

Pharmacokinetics And Pharmacodynamics ◽

Population Pharmacokinetics And Pharmacodynamics ◽

Cell Adhesion Molecule 1

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Population Pharmacokinetics and Pharmacodynamics of Ontamalimab (SHP647), a Fully Human Monoclonal Antibody Against Mucosal Addressin Cell Adhesion Molecule‐1 (MAdCAM‐1), in Patients With Ulcerative Colitis or Crohn's Disease

The Journal of Clinical Pharmacology ◽

10.1002/jcph.1590 ◽

2020 ◽

Vol 60 (7) ◽

pp. 903-914

Author(s):

Yi Wang ◽

Jean‐Francois Marier ◽

Jean Lavigne ◽

Nastya Kassir ◽

Patrick Martin

Keyword(s):

Ulcerative Colitis ◽

Monoclonal Antibody ◽

Cell Adhesion ◽

Population Pharmacokinetics ◽

Adhesion Molecule ◽

Cell Adhesion Molecule ◽

Human Monoclonal Antibody ◽

Pharmacokinetics And Pharmacodynamics ◽

Population Pharmacokinetics And Pharmacodynamics ◽

Cell Adhesion Molecule 1

Download Full-text

P037 LONG-TERM SAFETY, EFFICACY AND PHARMACOKINETICS OF THE ANTI-MUCOSAL ADDRESSIN CELL ADHESION MOLECULE-1 (MADCAM-1) MONOCLONAL ANTIBODY SHP647 IN CROHN’S DISEASE: THE OPERA II STUDY

Gastroenterology ◽

10.1053/j.gastro.2019.01.089 ◽

2019 ◽

Vol 156 (3) ◽

pp. S26-S27

Author(s):

Geert D’Haens ◽

Walter Reinisch ◽

Scott D. Lee ◽

Dino Tarabar ◽

Edouard Louis ◽

...

Keyword(s):

Monoclonal Antibody ◽

Crohn’S Disease ◽

Cell Adhesion ◽

Crohn's Disease ◽

Adhesion Molecule ◽

Cell Adhesion Molecule ◽

Cell Adhesion Molecule 1

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P036 LONG-TERM SAFETY AND EFFICACY OF THE ANTI-MUCOSAL ADDRESSIN CELL ADHESION MOLECULE-1 (MADCAM-1) ANTIBODY SHP647 IN ULCERATIVE COLITIS: AN OPEN-LABEL EXTENSION STUDY (TURANDOT II)

Gastroenterology ◽

10.1053/j.gastro.2019.01.088 ◽

2019 ◽

Vol 156 (3) ◽

pp. S25-S26

Author(s):

Walter Reinisch ◽

William J. Sandborn ◽

Silvio Danese ◽

Xavier Hébuterne ◽

Bruce Salzberg ◽

...

Keyword(s):

Ulcerative Colitis ◽

Cell Adhesion ◽

Adhesion Molecule ◽

Cell Adhesion Molecule ◽

Extension Study ◽

Open Label ◽

Safety And Efficacy ◽

Open Label Extension ◽

Cell Adhesion Molecule 1

Download Full-text

P037 LONG-TERM SAFETY, EFFICACY AND PHARMACOKINETICS OF THE ANTI-MUCOSAL ADDRESSIN CELL ADHESION MOLECULE-1 (MADCAM-1) MONOCLONAL ANTIBODY SHP647 IN CROHN’S DISEASE: THE OPERA II STUDY

Inflammatory Bowel Diseases ◽

10.1093/ibd/izy393.042 ◽

2019 ◽

Vol 25 (Supplement_1) ◽

pp. S18-S19

Author(s):

Geert D’Haens ◽

Walter Reinisch ◽

Scott D Lee ◽

Dino Tarabar ◽

Edouard Louis ◽

...

Keyword(s):

Monoclonal Antibody ◽

Crohn’S Disease ◽

Cell Adhesion ◽

Crohn's Disease ◽

Adhesion Molecule ◽

Cell Adhesion Molecule ◽

Cell Adhesion Molecule 1

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TREATMENT WITH ANTI-VASCULAR CELL ADHESION MOLECULE 1 MONOCLONAL ANTIBODY INDUCES LONG-TERM MURINE CARDIAC ALLOGRAFT ACCEPTANCE

Transplantation Journal ◽

10.1097/00007890-199308000-00039 ◽

1993 ◽

Vol 56 (2) ◽

pp. 453-460 ◽

Cited By ~ 78

Author(s):

CHARLES G. OROSZ ◽

RICHARD G. OHYE ◽

RONALD P. PELLETIER ◽

ANNE M. VAN BUSKIRK ◽

EMINA HUANG ◽

...

Keyword(s):

Monoclonal Antibody ◽

Cell Adhesion ◽

Adhesion Molecule ◽

Cell Adhesion Molecule ◽

Cardiac Allograft ◽

Vascular Cell Adhesion ◽

Vascular Cell ◽

Vascular Cell Adhesion Molecule ◽

Cell Adhesion Molecule 1

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Tu1728 – Long-Term Efficacy and Pharmacodynamics of the Anti-Mucosal Addressin Cell Adhesion Molecule-1 (Madcam-1) Monoclonal Antibody Shp647 in Crohn's Disease: the Opera Ii Study

Gastroenterology ◽

10.1016/s0016-5085(19)39714-8 ◽

2019 ◽

Vol 156 (6) ◽

pp. S-1101

Author(s):

Geert R. D'Haens ◽

Walter Reinisch ◽

Scott D. Lee ◽

Dino Tarabar ◽

Edouard Louis ◽

...

Keyword(s):

Monoclonal Antibody ◽

Crohn’S Disease ◽

Cell Adhesion ◽

Crohn's Disease ◽

Adhesion Molecule ◽

Cell Adhesion Molecule ◽

Term Efficacy ◽

Cell Adhesion Molecule 1

Download Full-text

P036 LONG-TERM SAFETY AND EFFICACY OF THE ANTI-MUCOSAL ADDRESSIN CELL ADHESION MOLECULE-1 (MADCAM-1) ANTIBODY SHP647 IN ULCERATIVE COLITIS: AN OPEN-LABEL EXTENSION STUDY (TURANDOT II)

Inflammatory Bowel Diseases ◽

10.1093/ibd/izy393.041 ◽

2019 ◽

Vol 25 (Supplement_1) ◽

pp. S18-S18 ◽

Cited By ~ 3

Author(s):

Walter Reinisch ◽

William J Sandborn ◽

Silvio Danese ◽

Xavier Hébuterne ◽

Bruce Salzberg ◽

...

Keyword(s):

Ulcerative Colitis ◽

Cell Adhesion ◽

Adhesion Molecule ◽

Cell Adhesion Molecule ◽

Extension Study ◽

Open Label ◽

Safety And Efficacy ◽

Open Label Extension ◽

Cell Adhesion Molecule 1

Download Full-text

Long-Term Safety of the Anti-Mucosal Addressin Cell Adhesion Molecule-1 (MAdCAM-1) Antibody SHP647 in Ulcerative Colitis: An Open-Label Extension Study (TURANDOT II)

The American Journal of Gastroenterology ◽

10.14309/00000434-201810001-00605 ◽

2018 ◽

Vol 113 (Supplement) ◽

pp. S347

Author(s):

Walter Reinisch ◽

William J. Sandborn ◽

Silvio Danese ◽

Xavier Hébuterne ◽

Bruce Salzberg ◽

...

Keyword(s):

Ulcerative Colitis ◽

Cell Adhesion ◽

Adhesion Molecule ◽

Cell Adhesion Molecule ◽

Extension Study ◽

Open Label ◽

Open Label Extension ◽

Cell Adhesion Molecule 1

Download Full-text

OP08 Long-term efficacy and pharmacodynamics of the anti-mucosal addressin cell adhesion molecule-1 (MAdCAM-1) monoclonal antibody SHP647 in Crohn’s disease: the OPERA II study

Journal of Crohn s and Colitis ◽

10.1093/ecco-jcc/jjy222.007 ◽

2019 ◽

Vol 13 (Supplement_1) ◽

pp. S005-S006 ◽

Cited By ~ 2

Author(s):

G D’Haens ◽

W Reinisch ◽

S D Lee ◽

D Tarabar ◽

E Louis ◽

...

Keyword(s):

Monoclonal Antibody ◽

Crohn’S Disease ◽

Cell Adhesion ◽

Crohn's Disease ◽

Adhesion Molecule ◽

Cell Adhesion Molecule ◽

Term Efficacy ◽

Cell Adhesion Molecule 1

Download Full-text