scholarly journals Paul Ehrlich †

1915 ◽  
Vol 41 (37) ◽  
pp. 1103-1106 ◽  
Author(s):  
A. von Wassermann
Keyword(s):  
1952 ◽  
Vol 20 (1) ◽  
pp. 185
Keyword(s):  

2012 ◽  
Vol 40 (06) ◽  
pp. 432-437
Author(s):  
V. Wunderlich
Keyword(s):  

ZusammenfassungDas Sticker-Sarkom (neuere Bezeichnung CTVT für canine transmissible venereal tumor) ist ein histiozytärer venerischer Tumor, der unter Hunden durch direkten Kontakt übertragen wird. Seit kurzem ist gesichert, dass alle weltweit vorkommenden Tumoren dieses Typs ursprünglich von dem Tumor eines Tieres abstammen. Das beim Kontakt übertragene infektiöse Agens ist die Krebszelle selbst. Damit stellt das StickerSarkom die älteste bekannte Krebslinie und heute zugleich das beste Modell für infektiöse Krebszellen dar. Das Sarkom ist nach dem deutschen Veterinärund Humanmediziner Anton Sticker (1861–1944) benannt, der in den Jahren 1902 bis 1905 im Frankfurter Institut von Paul Ehrlich umfangreiche Untersuchungen zur Natur des Tumors durchführte. Die wechselvolle und bisher wenig bekannte Laufbahn von Sticker wird kurz dargestellt.


BioScience ◽  
2020 ◽  
Vol 70 (11) ◽  
pp. 959-966
Author(s):  
James M Verdier

Abstract In Their Own Words chronicles the stories of scientists who have made great contributions to their fields. These short histories provide our readers a way to learn from and share their experiences. Each month, we will publish in the pages of BioScience and on our podcast, BioScience Talks (http://bioscienceaibs.libsyn.com), the results of these conversations. This history is with Paul Ehrlich, president of the Center for Conservation Biology and Bing Professor of Population Studies Emeritus at Stanford University. He is also a past president of AIBS. Note: Both the text and audio versions have been edited for clarity and length.


Blood ◽  
1954 ◽  
Vol 9 (5) ◽  
pp. 395-396
Author(s):  
WILLIAM DAMESHEK
Keyword(s):  

1919 ◽  
Vol 7 (11) ◽  
pp. 165-168 ◽  
Author(s):  
Leonor Michaelis
Keyword(s):  

1952 ◽  
Vol 223 (1) ◽  
pp. 113
Author(s):  
&NA; E K
Keyword(s):  

Author(s):  
A. M. Gressner ◽  
O. A. Gressner
Keyword(s):  

Author(s):  
Maria José Saavedraa ◽  
João Carlos Sousa

Resumo A elevada mortalidade pelas doenças infecciosas, sobretudo epidémicas, mobilizou os cientistas na pesquisa de compostos naturais e produtos de síntese química dotados de propriedades antimicrobianas. Fazendo um pouco de história, referimos Paul Ehrlich, que utilizou o primeiro agente quimioterapêutico -Salvarsan, mais tarde Gerhard Domagk, que utilizou um pro-fármaco percursor de uma sulfamida. Em 1928, Alexander Fleming, descobriu de forma “casual” a penicilina, o primeiro antibiótico. Posteriormente em 1941 Howard Florey e Ernest Chain isolam e purificam a penicilina o que permitiu a sua utilização em larga escala -Era dos Antibióticos. A utilização dos antibióticos (AB) no tratamento das doenças infecciosas constituiu um dos maiores avanços da Medicina no séc. XX. No entanto a sua utilização em larga escala promoveu o aumento da incidência de estirpes multiresistentes aos AB, sobretudo em ambiente hospitalar. Adicionalmente verifica-se uma ocorrência cada vez mais elevada de estirpes resistentes na comunidade–humanos, animais e ambiente. O conhecimento dos mecanismos de ação e da ineficácia dos diferentes grupos farmacológicos de antibióticos é vital para o desenvolvimento de futuros microbianos, estando a ser estudados microrganismos do solo com a finalidade de encontrara novos fármacos. De realçar que a OMS preconiza que caminhamos rumo a uma "era pós-antibiótico”. Se não houver um plano de ação global para o "uso racional de antibióticos" a OMS prevê que em 2050 a resistência aos antibióticos, poderá matar mais de 10 milhões de pessoas.Palavras-chave: antibioterapia; resistência; antibióticos Abstract The current research on infectious diseases, especially with epidemic potential, has mobilized the scientific community to research on the natural substance and chemical probing products with antimicrobial properties. In a brief history of antibiotics, we refer to Paul Ehrlich, who used the first chemotherapeutic agent - Salvarsan, later Gerhard Domagk, who used a sulfamide precursor prodrug. In 1928 Alexander Fleming "casually" discovered penicillin, the first antibiotic. Later in 1941 Howard Florey and Ernest Chain isolate and purify penicillin that can be used on a large scale - Antibiotics Era. The use of antibiotics (AB) in the treatment of infectious diseases is one of the greatest advances of medicine in the 19th century. However, its large-scale use has increased the incidence of multidrug-resistant processes in AB, especially in a hospital setting. Besides, there is an increasing occurrence of resistant strains in different communities - humans, animals and in the environment. Understand the mechanisms of action and the ineffectiveness of the diverse pharmacological groups of antibiotics is crucial to provide further new antibiotic therapies in the near future. Recent studies have highlighted the soil-derived microorganisms as a novel approach to identify new drug substances. In this context, it is noteworthy that the World Health Organization (WHO) considers that we are moving towards a “post-antibiotic era”. If there is no global action plan for “rational use of antibiotics” WHO predicts that in 2050 the global impacts of antibiotic resistance on human heath will be catastrophic, killing more than 10 million people worldwide. Keywords: antibiotic therapy; resistence; antibiotics


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