Abstract
Purpose To compare the diagnostic performance of double contrast-enhanced ultrasound (DCEUS) and multi-detector row computed tomography (MDCT) in the gross classification of gastric cancer (GC) preoperatively. Methods 54 patients with GC proved by histology were included in this study. The sensitivity and specificity of DCEUS and MDCT for gross classification were calculated and compared. The area under the curve (AUC) from a receiver operating characteristic curve analysis was used to evaluate the difference of the diagnostic performance between these two methods.Results There were no significant differences between DCEUS and MDCT in terms of AUC values for early gastric cancer (EGC) and Borrmann Ⅰ-Ⅲ (P = 0.248, 0.317, 0.717 and 0.464, respectively). However, the sensitivities of DCEUS for EGC, Borrmann Ⅰ and Borrmann Ⅲ were higher than those of MDCT (75% versus 62%; 100% versus 50%; 90% versus 73%). The specificity of DCEUS for Borrmann Ⅲ was lower than that of MDCT (50% versus 75%). The AUC value of MDCT for Borrmann Ⅳ was significantly higher than that of DCEUS (0.927 versus 0.625; P=0.001). The accuracy and specificity of DCEUS and MDCT for Borrmann Ⅳ were similar, but the sensitivity of MDCT was significantly higher than that of DCEUS (88% versus 25%).Conclusion DCEUS may be considered as a useful complementary imaging modality to MDCT for the evaluation of the gross classification of GC preoperatively.
Double Contrast-enhanced Ultrasound for the Preoperative Gross Classification of Gastric Cancer: a Comparison With Multidetector Computed Tomography