Synthesis of the Tripeptide Antibiotic Resormycin
Keyword(s):
A short and efficient synthesis of resormycin, a metabolite of Streptomyces platensis MJ953-SF5 with herbicidal and antifungal activity, is described. The key step in our synthetic approach is a late-stage stereospecific dehydration of a β-hydroxy amino acid to install the Z-olefin. Because of the modular nature of the synthesis, access to analogues for biological evaluation is readily available.
1965 ◽
Vol 14
(11)
◽
pp. 1954-1957
Keyword(s):
1965 ◽
Vol 14
(12)
◽
pp. 2195-2195
Keyword(s):
1957 ◽
Vol 44
(8)
◽
pp. 471-476
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2014 ◽
Vol 25
(9)
◽
pp. 1215-1219
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Keyword(s):
1977 ◽
Vol 50
(4)
◽
pp. 917-920
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