A Short Asymmetric Synthesis of Sauropunols A–D
A short and efficient asymmetric synthesis of natural sauropunols A, B, and C/D has been accomplished in 6 steps from divinylcarbinol with overall yield of 19%, 7% and 32%, respectively. The key synthetic steps include effective Sharpless asymmetric epoxidation of penta-1,4-dien-3-ol and a highly diastereoselective Pd-catalysed oxycarbonylation of pentene-1,2,3-triol. The structures of sauropunols A and B have been confirmed.
1984 ◽
Vol 62
(11)
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pp. 2148-2154
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1991 ◽
Vol 113
(7)
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pp. 2786-2787
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2011 ◽
Vol 2011
(15)
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pp. 2777-2780
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