Synthesis of Novel Isoquinolino[5,4-ab]phenanthridine Derivatives via Pictet–Spengler Reaction
The reaction of 5-amino-2-[2-(dimethylamino)ethyl]-6-phenyl-1H-benzo[de]isoquinoline-1,3(2H)-dione with a series of aldehydes in acidic media (phosphoric acid, trifluoromethanesulfonic acid, and trifluoroacetic acid) is described. This key step is based on the Pictet–Spengler reaction to synthesize ten novel isoquinolino[5,4-ab]phenanthridine derivatives. The most effective acid is phosphoric acid and optimized yields were obtained. The frameworks of target compounds are unique and have never been reported.
1991 ◽
Vol 39
(10)
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pp. 2718-2720
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1986 ◽
Vol 108
(17)
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pp. 5242-5251
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1996 ◽
Vol 146
(1)
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pp. 107-117
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1992 ◽
Vol 0
(12)
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pp. 916-917
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2009 ◽
Vol 155
(3)
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pp. 580-585
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1991 ◽
Vol 147
(2)
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pp. 309-319
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