Acidity dependence of the trifluoromethanesulfonic acid catalyzed isobutane-isobutylene alkylation modified with trifluoroacetic acid or water

The acid catalyzed condensation of cyclohexenylacetic acid and its corresponding N-methylamide with formaldehyde was investigated. Good yields of the expected δ-lactone (V) or δ-lactam (IX) were obtained when trifluoroacetic acid was used both as catalyst and solvent for the reaction.

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Trifluoroacetic acid catalyzed highly regioselective bromocyclization of styrene-type carboxylic acid

Organic & Biomolecular Chemistry ◽

10.1039/c6ob00756b ◽

2016 ◽

Vol 14 (20) ◽

pp. 4571-4575 ◽

Cited By ~ 16

Author(s):

Tao Chen ◽

Ying-Yeung Yeung

Keyword(s):

Carboxylic Acid ◽

Trifluoroacetic Acid ◽

Acid Catalyzed

A trifluoroacetic acid catalyzed highly 6-endo regioselective bromocyclization of styrene-type carboxylic acid has been developed.

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ChemInform Abstract: TRIFLUOROACETIC ACID CATALYZED ALLYLIC PHENYLATION OF α-METHYLALLYL ACETATE, α-METHYLALLYL TRIFLUOROACETATE, AND α-METHYLALLYL ALCOHOL WITH BENZENE

Chemischer Informationsdienst ◽

10.1002/chin.198516188 ◽

1985 ◽

Vol 16 (16) ◽

Author(s):

Y. FUJIWARA ◽

H. KUROMARU ◽

H. TANIGUCHI

Keyword(s):

Trifluoroacetic Acid ◽

Acid Catalyzed

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ChemInform Abstract: Mechanisms for the Removal of Benzyl Protecting Groups in Synthetic Peptides by Trifluoromethanesulfonic Acid - Trifluoroacetic Acid - Dimethyl Sulfide.

Chemischer Informationsdienst ◽

10.1002/chin.198652281 ◽

1986 ◽

Vol 17 (52) ◽

Author(s):

J. P. TAM ◽

W. F. HEATH ◽

R. B. MERRIFIELD

Keyword(s):

Trifluoroacetic Acid ◽

Synthetic Peptides ◽

Dimethyl Sulfide ◽

Trifluoromethanesulfonic Acid ◽

Protecting Groups

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The cationic oligomerization of p-aminostyrene 1. Trifluoroacetic acid-catalyzed polyaddition

Polymer Bulletin ◽

10.1007/s002890070021 ◽

2000 ◽

Vol 45 (3) ◽

pp. 199-206 ◽

Cited By ~ 3

Author(s):

Takeo Hamaya

Keyword(s):

Trifluoroacetic Acid ◽

Acid Catalyzed

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Synthesis of Novel Isoquinolino[5,4-ab]phenanthridine Derivatives via Pictet–Spengler Reaction

Synthesis ◽

10.1055/s-0037-1610670 ◽

2018 ◽

Vol 51 (06) ◽

pp. 1377-1382

Author(s):

Tzenge-Lien Shih ◽

Min-Chen Tsai ◽

Pei Huang ◽

Liang Syu

Keyword(s):

Phosphoric Acid ◽

Trifluoroacetic Acid ◽

Trifluoromethanesulfonic Acid ◽

Acidic Media

The reaction of 5-amino-2-[2-(dimethylamino)ethyl]-6-phenyl-1H-benzo[de]isoquinoline-1,3(2H)-dione with a series of aldehydes in acidic media (phosphoric acid, trifluoromethanesulfonic acid, and trifluoroacetic acid) is described. This key step is based on the Pictet–Spengler reaction to synthesize ten novel isoquinolino[5,4-ab]phenanthridine derivatives. The most effective acid is phosphoric acid and optimized yields were obtained. The frameworks of target compounds are unique and have never been reported.

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