Lewis Acid-Catalyzed Rearrangement of Fluoroalkylated Propargylic Alcohols: An Alternative Approach to β-Fluoroalkyl-α,β-enones
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A practical Lewis acid-catalyzed Meyer–Schuster rearrangement of fluoroalkylated propargylic alcohols, leading to a series of β-fluoroalkyl-α,β-enones, is developed. The methodology reported herein features moderate to high yields and high stereoselectivity in the synthesis of β-alkyl-β-fluoroalkyl-α,β-enones.
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2014 ◽
Vol 10
◽
pp. 2892-2896
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2018 ◽
Vol 360
(15)
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pp. 2796-2800
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2020 ◽
Vol 362
(6)
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pp. 1399-1404
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