Whole-Body and Renal Clearance of 203Hg-Chlormerodrin. The Effect of Chelating Agents on Clearance
Keyword(s):
The Body
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SummaryUsing a whole-body counter, normal whole-body and renal clearances of 203Hg-chlormerodrin and the action of L-cysteine and D-penicillamine as chelating agents have been studied in 19 subjects.L-cysteine and D-penicillamine given in varying doses at different time intervals did not change the whole-body or renal retention of mercury. This indicates that these chelating agents are not effective when mercury is present in the body in minute quantities. The search for better and more convenient renal scanning agents should continue, as should also the search for a better chelating agent to enhance clearance of 203Hg from the body.