The Influence of Lactate and Dipyridamole on Myocardial Fatty Acid Metabolism in Man, Traced with 123l-17-lodo-heptadecanoic Acid

1990 ◽  
Vol 29 (01) ◽  
pp. 28-34 ◽  
Author(s):  
F. C. Visser ◽  
M. J. van Eenige ◽  
G. Westera ◽  
J. P. Roos ◽  
C. M. B. Duwel
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Time Activity ◽  
Time Value ◽  
Myocardial Fatty Acid Metabolism ◽  
Coronary Vasodilatation ◽  
Activity Curve ◽  
Normal Human ◽  
Plasma Lactate Level

Changes in myocardial metabolism can be detected externally by registration of time-activity curves after administration of radioiodinated fatty acids. In this scintigraphic study the influence of lactate on fatty acid metabolism was investigated in the normal human myocardium, traced with 123l-17-iodoheptadecanoic acid (123l-17-HDA). In patients (paired, n = 7) lactate loading decreased the uptake of 123l-17-HDA significantly from 27 (control: 22-36) to 20 counts/min/pixel (16-31; p <0.05 Wilcoxon). The half-time value increased to more than 60 rriin (n = 5), oxidation decreased from 61 to 42%. Coronary vasodilatation, a well-known side effect of lactate loading, was studied separately in a dipyridamole study (paired, n = 6). Coronary vasodilatation did not influence the parameters of the time-activity curve. These results suggest that changes in plasma lactate level as occurring, among other effects, during exercise will influence the parameters of dynamic 123l-17-HDA scintigraphy of the heart.

Radionuclide assessment of myocardial fatty acid metabolism by PET and SPECT

1995 ◽  
Vol 2 (3) ◽  
pp. 256-266 ◽  
Author(s):  
N TAMAKI ◽  
Y FUJIBAYASHI ◽  
Y MAGATA ◽  
Y YONEKURA ◽  
J KONISHI
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Myocardial Fatty Acid ◽  
Myocardial Fatty Acid Metabolism

scholarly journals Longitudinal Evaluation of Fatty Acid Metabolism in Normal and Spontaneously Hypertensive Rat Hearts with Dynamic MicroSPECT Imaging

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Bryan W. Reutter ◽  
Ronald H. Huesman ◽  
Kathleen M. Brennan ◽  
Rostyslav Boutchko ◽  
Stephen M. Hanrahan ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Spontaneously Hypertensive Rat ◽  
Projection Data ◽  
Ct Scanner ◽  
Pinhole Spect ◽  
Time Activity ◽  
Spontaneously Hypertensive ◽  
Hypertensive Rat

The goal of this project is to develop radionuclide molecular imaging technologies using a clinical pinhole SPECT/CT scanner to quantify changes in cardiac metabolism using the spontaneously hypertensive rat (SHR) as a model of hypertensive-related pathophysiology. This paper quantitatively compares fatty acid metabolism in hearts of SHR and Wistar-Kyoto normal rats as a function of age and thereby tracks physiological changes associated with the onset and progression of heart failure in the SHR model. The fatty acid analog, 123I-labeled BMIPP, was used in longitudinal metabolic pinhole SPECT imaging studies performed every seven months for 21 months. The uniqueness of this project is the development of techniques for estimating the blood input function from projection data acquired by a slowly rotating camera that is imaging fast circulation and the quantification of the kinetics of 123I-BMIPP by fitting compartmental models to the blood and tissue time-activity curves.

scholarly journals L-carnitine Improved the Cardiac Function via the Effect on Myocardial Fatty Acid Metabolism in a Hemodialysis Patient

2018 ◽  
Vol 57 (24) ◽  
pp. 3593-3596 ◽  
Author(s):  
Mai Kaneko ◽  
Hirotaka Fukasawa ◽  
Kento Ishibuchi ◽  
Hiroki Niwa ◽  
Hideo Yasuda ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Cardiac Function ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Hemodialysis Patient ◽  
Myocardial Fatty Acid ◽  
Myocardial Fatty Acid Metabolism
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