Antibody to Hepatitis C Virus after a Vapor Heated Factor VIII Concentrate – Lack of Evidence

1991 ◽  
Vol 66 (05) ◽  
pp. 620-620
Author(s):  
Klaus Anderle ◽  
Gerald Eder ◽  
Johann Eibl
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Factor Viii

Antibody to Hepatitis G Mrus after a Vapour-Heated Factor Vlll Goncentrate

1990 ◽  
Vol 64 (02) ◽  
pp. 232-234 ◽  
Author(s):  
P M Mannucci ◽  
A R Zanetti ◽  
M Colombo ◽  
A Chistolini ◽  
R De Biasi ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B ◽  
Factor Viii ◽  
Alanine Aminotransferase ◽  
Household Contact ◽  
Clotting Factor ◽  
Double Infection ◽  
Marked Elevation ◽  
Clotting Factor Concentrates

SummaryTo evaluate whether or not clotting factor concentrates exposed to virucidal procedures transmitted hepatitis C, sera obtained in 1984–1986 from 27 previously untreated hemophiliacs infused with a vapour-heated factor VIII concentrate were tested retrospectively for the antibody to the hepatitis C virus (anti- HCV). A 2-year-old hemophiliac, negative for anti-HCV before administration of concentrate, seroconverted at week 12 and remained anti-HCV positive thereafter. Both his parents were anti-HCV negative and he had no other household contact. The patient had also become HBsAg positive at week 8 and had at the same time a marked elevation of alanine aminotransferase. His double infection with the hepatitis B and C viruses indicates that hot vapour was not completely effective in inactivating these viruses.

scholarly journals Recombinant hepatitis C virus in experimentally infected chimpanzees

2007 ◽  
Vol 88 (1) ◽  
pp. 143-147 ◽  
Author(s):  
Fengxiang Gao ◽  
Omana V. Nainan ◽  
Yuri Khudyakov ◽  
Jinfeng Li ◽  
Ying Hong ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Sequence Analysis ◽  
Factor Viii ◽  
Genetic Recombination ◽  
Nucleotide Sequences ◽  
Recombinant Hepatitis ◽  
Rt Pcr ◽  
Crossover Region ◽  
Different Strains

Genetic recombination between different strains of Hepatitis C virus (HCV) was investigated in three chimpanzees inoculated experimentally with factor VIII concentrate containing HCV subgenotypes 1a, 1b, 2b and 3a. A 750 bp long fragment from the HCV envelope region was amplified by RT-PCR and quasispecies were isolated by plasmid cloning. Nucleotide sequences derived from isolated quasispecies were screened for the presence of inter-subgenotypic recombination by using sequence analysis. Recombination between HCV subgenotype 1a and 1b was found in two animals; each recombinant variant differed by location of predicted crossover region or order of subgenotype 1a and 1b sequences.

Hepatitis C virus: Buoyant density if the factor VIII-derived isolate in sucrose

1991 ◽  
Vol 34 (3) ◽  
pp. 206-208 ◽  
Author(s):  
D. Bradley ◽  
K. McCaustland ◽  
K. Krawczynski ◽  
J. Spelbring ◽  
C. Humphey ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Factor Viii ◽  
Buoyant Density

scholarly journals Acquisition of Factor VIII Inhibitor After Acute Hepatitis C Virus Infection

Blood ◽  
1997 ◽  
Vol 90 (8) ◽  
pp. 3233-3233 ◽  
Author(s):  
N. Dentale ◽  
C. Fulgaro ◽  
L. Guerra ◽  
G. Fasulo ◽  
M. Mazzetti ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Factor Viii ◽  
Acute Hepatitis ◽  
Factor Viii Inhibitor ◽  
Acute Hepatitis C ◽  
Hepatitis C Virus Infection ◽  
Viii Inhibitor

The impact of hepatitis C antibody screening of source plasma donors on hepatitis C virus RNA in factor VIII concentrates

Haemophilia ◽  
1995 ◽  
Vol 1 (4) ◽  
pp. 249-254 ◽  
Author(s):  
ERIK BERNTORP ◽  
STEFAN LETHAGEN ◽  
ERIK NORDENFELT ◽  
ANN-SOFIE MÅNSSON ◽  
SIV MÅNSSON ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Factor Viii ◽  
Hepatitis C Virus Rna ◽  
Antibody Screening ◽  
Virus Rna ◽  
Factor Viii Concentrates ◽  
The Impact

Reactivation of Chronic Hepatitis C Virus Infection by Immunoadsorption in Factor VIII Inhibitor Haemophilia

2000 ◽  
Vol 84 (10) ◽  
pp. 733-734 ◽  
Author(s):  
Franz Rommel ◽  
Josef Eberle ◽  
Helmut Schiffl ◽  
Michael Spannagl ◽  
Wolfgang Schramm ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Virus Infection ◽  
Factor Viii ◽  
Chronic Hepatitis C ◽  
Factor Viii Inhibitor ◽  
Hepatitis C Virus Infection ◽  
Chronic Hepatitis C Virus ◽  
Viii Inhibitor
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