Decreased Fibrinolysis in Reperfused Ischaemic Tissue

1974 ◽  
Vol 32 (02/03) ◽  
pp. 659-664 ◽  
Author(s):  
G. W Cherry ◽  
T. J Ryan ◽  
J. E Ellis
Keyword(s):  
Blood Supply ◽  
Femoral Artery ◽  
Fibrinolytic Activity ◽  
Marked Reduction ◽  
Vascular Pathology ◽  
Contributory Factor ◽  
Dramatic Reduction ◽  
Skin Flaps ◽  
Ischaemia And Reperfusion ◽  
Total Interference

SummaryThe fibrinolytic activity of skin flaps subjected to ischaemia and reperfusion was studied in five pigs. Total interference with the blood supply up to 24 hours did not in itself lead to changes in fibrinolytic activity. However, reperfusion of the skin after six hours of ischaemia caused a dramatic reduction in fibrinolytic activity measured 18 hours later.Similar studies on reperfused femoral artery and vein after six hours of ischaemia showed marked reduction in fibrinolytic activity of the vessels.It is suggested that reperfusion of tissue made ischaemic for six hours is damaging and might be a contributory factor to vascular pathology.

Basic Skin Flaps and Blood Supply

2022 ◽  
pp. 15-26
Author(s):  
Edwin Morrison ◽  
Wayne A.J. Morrison
Keyword(s):  
Blood Supply ◽  
Skin Flaps

Cutaneous Vascular Anatomy of Pectoral Skin Flaps

1973 ◽  
Vol 82 (5) ◽  
pp. 691-695
Author(s):  
Thomas C. Calcaterra ◽  
Edward F. Cherney ◽  
Mohammed Saffouri
Keyword(s):  
Head And Neck ◽  
Blood Supply ◽  
Surgical Therapy ◽  
Vascular Anatomy ◽  
Skin Flaps ◽  
Flap Necrosis ◽  
Arterial Blood Supply ◽  
Pedicled Flaps ◽  
Arterial Blood ◽  
Flap Viability

The need for nondelayed skin flaps from the chest for postoperative reconstruction and repair has increased considerably since the advent of combined irradiation and surgical therapy for treatment of cancer of the head and neck. Survival of these pedicled flaps is of paramount concern to the surgeon, as flap necrosis can be catastrophic for the patient. Many parameters have been evaluated to predict flap viability, but recent studies strongly suggest that the arterial blood supply of the pedicle is the most important factor in the success of immediate transposition. A study was performed in 19 cadavers to delineate the cutaneous vascular anatomy of the chest in order to determine precisely where the perforating vessels of the thorax and shoulders supply the pedicle region of medially-based and laterally-based pectoral flaps. On the basis of this study, modification of the design of these flaps is recommended.

Decreased Myocardial Fibrinolytic Activity Following Temporary Ischaemia and Reperfusion

1975 ◽  
Vol 34 (01) ◽  
pp. 210-215
Author(s):  
George W Cherry ◽  
L. H Opie
Keyword(s):  
Myocardial Ischaemia ◽  
Fibrinolytic Activity ◽  
Endothelial Damage ◽  
Myocardial Tissue ◽  
Ischaemia And Reperfusion ◽  
Reperfused Myocardium

SummaryThe effect of temporary myocardial ischaemia (x 52 mins) and reperfusion (x 23 hrs 8 mins) on myocardial tissue fibrinolysis and 12 5I fibrinogen incorporation into fibrin was investigated in nine baboons.Fibrinolytic activity was reduced by 54% in the endocardium of the ischaemic reperfused myocardium and the 12 5I fibrinogen activity was elevated by 480%.The reduction in myocardial fibrinolytic activity following ischaemia and reperfusion may be due to endothelial damage.

scholarly journals Augmented P2X response and immunolabeling in dorsal root ganglion neurons innervating skeletal muscle following femoral artery occlusion

2013 ◽  
Vol 109 (8) ◽  
pp. 2161-2168 ◽  
Author(s):  
Jihong Xing ◽  
Jian Lu ◽  
Jianhua Li
Keyword(s):  
Dorsal Root Ganglion ◽  
Blood Supply ◽  
Femoral Artery ◽  
Dorsal Root ◽  
Artery Occlusion ◽  
Dorsal Root Ganglion Neurons ◽  
Drg Neurons ◽  
Transient Currents ◽  
Femoral Artery Occlusion ◽  
Ganglion Neurons

The responsiveness of sensory neurons to muscle metabolites is altered under the conditions of insufficient limb blood supply in some diseases, such as peripheral artery disease. The purpose of this study was to examine ATP-induced current with activation of purinergic P2X subtypes P2X3 and P2X2/3 in dorsal root ganglion (DRG) neurons of control limbs and limbs with 24 h of femoral artery occlusion using whole cell patch-clamp methods. Also, dual-labeling immunohistochemistry was employed to determine existence of P2X3 expression in DRG neurons of thin-fiber afferents. DRG neurons from 4- to 6-wk-old rats were labeled by injecting the fluorescence tracer DiI into the hindlimb muscles 4–5 days before the recording experiments. Transient (P2X3), mixed (P2X3 and P2X2/3), and sustained (P2X2/3) current responses to α,β-methylene ATP (a P2X receptor agonist) are observed in small and medium DRG neurons, and size distribution of DRG neurons is similar in control and occluded limbs. However, the peak current amplitude of DRG neuron induced by stimulation of P2X3 and/or P2X2/3 is larger in occluded limbs than that in control limbs. Moreover, the percentage of DRG neurons with P2X3 transient currents is greater after arterial occlusion compared with control. In addition, a rapid desensitization was observed in DRG neurons with transient currents, but not with sustained currents in control and occluded groups. Furthermore, results from immunofluorescence experiments show that femoral artery occlusion primarily augments P2X3 expression within DRG neurons projecting C-fiber afferents. Overall, these findings suggest that 1) greater ATP-induced currents with activation of P2X3 and P2X2/3 are developed when hindlimb arterial blood supply is deficient under ischemic conditions and 2) increased P2X3 expression is largely observed in C-fibers of DRG neurons after hindlimb vascular insufficiency.

Basic skin flaps and blood supply

2015 ◽  
pp. 12-21
Author(s):  
Edwin J. Morrison ◽  
Wayne A.J. Morrison
Keyword(s):  
Blood Supply ◽  
Skin Flaps

Skin flaps

2021 ◽  
pp. 39-50
Author(s):  
Donald Dewar
Keyword(s):  
Blood Supply ◽  
Subcutaneous Tissue ◽  
Skin Flap ◽  
Donor Site ◽  
Pedicled Flap ◽  
Local Flaps ◽  
Skin Flaps ◽  
Local Skin ◽  
Recipient Vessel ◽  
Composite Defect

Flaps can reconstruct defects of the integument, resurface mucosal defects, as well as contribute to contour. They are used where grafting is not feasible because of the nature of the defect and/or where the aims of reconstruction would be better served by vascularized tissue with both cutaneous and subcutaneous components. A skin flap can also be combined with fascia, muscle, or bone to reconstruct a complex or composite defect, and to provide tissue to restore function. Flaps may be classified according to the origin of the flap: local skin flaps are raised from tissue adjacent to the defect (usually deriving their blood supply from the subcutaneous tissue and subdermal plexus), and distant flaps are raised on dedicated vascular pedicles from a non-contiguous region. A distant flap may be moved to the defect maintaining the continuity of the pedicle (a ‘regional’ or ‘pedicled’ flap) or as a free flap, where the flap is elevated from its remote donor site and the pedicle is divided to allow the flap to be transported ‘free’ to the defect and then the vascular continuity is re-established by anastomosis to a recipient vessel in the defect. This chapter focuses on local flaps.

scholarly journals Collateral blood supply to common femoral artery from intercostal arteries

2014 ◽  
Vol 2 ◽  
pp. 133-134
Author(s):  
Kudret Keskin ◽  
Murat Baskurt ◽  
Faruk Akturk
Keyword(s):  
Blood Supply ◽  
Femoral Artery ◽  
Common Femoral Artery
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