Decreased Myocardial Fibrinolytic Activity Following Temporary Ischaemia and Reperfusion

1975 ◽  
Vol 34 (01) ◽  
pp. 210-215
Author(s):  
George W Cherry ◽  
L. H Opie
Keyword(s):  
Myocardial Ischaemia ◽  
Fibrinolytic Activity ◽  
Endothelial Damage ◽  
Myocardial Tissue ◽  
Ischaemia And Reperfusion ◽  
Reperfused Myocardium

SummaryThe effect of temporary myocardial ischaemia (x 52 mins) and reperfusion (x 23 hrs 8 mins) on myocardial tissue fibrinolysis and 12 5I fibrinogen incorporation into fibrin was investigated in nine baboons.Fibrinolytic activity was reduced by 54% in the endocardium of the ischaemic reperfused myocardium and the 12 5I fibrinogen activity was elevated by 480%.The reduction in myocardial fibrinolytic activity following ischaemia and reperfusion may be due to endothelial damage.

Impaired Fibrinolysis in Sickle Cell Disease

1970 ◽  
Vol 24 (01/02) ◽  
pp. 010-016 ◽  
Author(s):  
D Green ◽  
H. C Kwaan ◽  
G Ruiz
Keyword(s):  
Sickle Cell Disease ◽  
Factor Viii ◽  
Plasminogen Activator ◽  
Sickle Cell ◽  
Fibrinolytic Activity ◽  
Endothelial Damage ◽  
Cell Disease ◽  
Clotting Factors ◽  
Platelet Counts

SummaryCoagulation studies were performed in 52 patients with sickle cell disease during asymptomatic periods and during episodes of crisis and infection. Platelet counts averaged 473,000, 469,000, and 461,000 per mm3 in these 3 groups, and factor VIII concentrations were elevated in all. Fibrinogen was increased to the same extent in both sickle cell and non-sickle cell patients with infection. Fibrinolytic activity, as measured by euglobulin lysis times and zones of lysis on fibrin plates, was markedly reduced during periods of infection in sickle cell patients but not in non-sickle patients. Impairment of fibrinolysis in most patients was not on the basis of overutilization or consumption, since no decrease in the levels of clotting factors or plasminogen was observed. It was suggested that generalized intravascular sickling in these patients may have caused widespread endothelial damage, resulting in decreased production of plasminogen activator.In addition, several sickle cell patients with infection were found to possess elevated levels of an inhibitor directed against urokinase.

scholarly journals Myocardial and coronary endothelial protective effects of acetylcholine after myocardial ischaemia and reperfusion in rats: role of nitric oxide

1995 ◽  
Vol 115 (8) ◽  
pp. 1532-1538 ◽  
Author(s):  
Vincent Richard ◽  
Thierry Blanc ◽  
Nathalie Kaeffer ◽  
Christophe Tron ◽  
Christian Thuillez
Keyword(s):  
Nitric Oxide ◽  
Myocardial Ischaemia ◽  
Protective Effects ◽  
Ischaemia And Reperfusion
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