Anticoagulation by Constant Subcutaneous Heparin Infusion

1982 ◽  
Vol 47 (01) ◽  
pp. 001-002 ◽  
Author(s):  
Nenita Parrilla ◽  
Jack Ansell
Keyword(s):  
Clinical Trial ◽  
Impedance Plethysmography ◽  
High Dose ◽  
Intravenous Therapy ◽  
Heparin Dose ◽  
Heparin Infusion ◽  
Subcutaneous Infusion ◽  
Subcutaneous Heparin ◽  
Therapeutic Anticoagulation ◽  
Continuous Subcutaneous Infusion

SummaryA preliminary clinical trial was conducted to determine the feasibility of achieving and regulating therapeutic anticoagulation with heparin given by continuous subcutaneous infusion. Five patients with deep venous thrombosis confirmed by impedance plethysmography and/or venography were studied. All patients received an initial heparin dose of 5000 units by IV bolus. This was followed by a continuous subcutaneous heparin infusion at a dose of 15 to 25 units per kilogram per hour. Effective levels of anticoagulation were achieved in all five patients. Regulation and maintenance of therapeutic anticoagulation were no more difficult than with intravenous therapy. No major complications were encountered during therapy.Continuous subcutaneous infusion of heparin may have advantages over standard intravenous therapy or high dose intermittent subcutaneous therapy. However, more extensive clinical evaluation is warranted.

Continuous Subcutaneous Heparin Infusion for Treatment of Trousseau's Syndrome

1995 ◽  
Vol 29 (7-8) ◽  
pp. 710-713 ◽  
Author(s):  
Christopher P Alderman ◽  
Anna F McClure ◽  
Hubertus PA Jersmann ◽  
Shane D Scott
Keyword(s):  
Oral Anticoagulants ◽  
Metastatic Carcinoma ◽  
Ambulatory Setting ◽  
Heparin Infusion ◽  
Subcutaneous Injections ◽  
Subcutaneous Infusion ◽  
Trousseau’S Syndrome ◽  
Subcutaneous Heparin ◽  
Continuous Subcutaneous Infusion ◽  
Effective Option

Objective: To describe the use of continuous subcutaneous heparin infusion in the treatment of 2 cases of Trousseau's syndrome. Case Summaries: Two patients with metastatic carcinoma presented to the hospital with acute coagulopathies consistent with a diagnosis of Trousseau's syndrome. In both cases conventional anticoagulant therapies proved to be impractical and ineffective. Discussion: Considerable literature suggests that oral anticoagulants such as warfarin are ineffective in the treatment of Trousseau's syndrome. Heparin is more effective for this purpose, although continuous intravenous infusion may prove difficult in the ambulatory setting. Intermittent subcutaneous injections of heparin or low-molecular-weight heparin may not provide reliable anticoagulation for the entire dosage interval. Although the use of continuous subcutaneous infusion of heparin has been used for anticoagulation during pregnancy, this is the first report of the use of sodium heparin administered by continuous subcutaneous infusion in the treatment of Trousseau's syndrome. Conclusions: Continuous subcutaneous heparin infusion may be an effective option for the treatment of Trousseau's syndrome in the ambulatory setting.

Administration of High-Dose Octreotide (Sandostatin) by Continuous Subcutaneous Infusion for the Treatment of Acromegaly

1990 ◽  
Vol 33 (1) ◽  
pp. 13-19
Author(s):  
M.C. White ◽  
R.A. James ◽  
S. Chatterjee ◽  
M. Mother ◽  
K. Hall ◽  
...  
Keyword(s):  
High Dose ◽  
Subcutaneous Infusion ◽  
Continuous Subcutaneous Infusion
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