Sciatic Nerve to Pudendal Nerve Transfer: Anatomical Feasibility for a New Proposed Technique

Abstract Aim Restoration of bladder and bowel continence after pudendal nerve anastomosis has been shown successfully in animal models and may be applicable in humans. Aim of this cadaveric study was to assess feasibility of pudendal nerve neurotization using motor fascicles from sciatic nerve. Methods Pudendal and sciatic nerves were exposed via gluteal approach in 5 human cadavers (10 sites). Size of pudendal and sciatic nerves and the distance between two nerves was measured. Results There were four male and one female cadavers. Mean age was 62 (range, 50–70) years. Mean pudendal nerve diameter was 2.94 mm (right side) and 2.82 mm (left side). Mean sciatic nerve diameter was 11.2 mm (right side) and 14.2 mm (left side). The distance between two nerves was 23.4 mm on both sides. Conclusion Transfer of the motor fascicles from sciatic nerve to pudendal nerve to restore the bladder and bowel continence is feasible.

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Feasibility of Neurovascular Antropylorus Perineal Transposition With Pudendal Nerve Anastomosis Following Anorectal Excision: A Cadaveric Study for Neoanal Reconstruction

Annals of Coloproctology ◽

10.3393/ac.2013.29.1.7 ◽

2013 ◽

Vol 29 (1) ◽

pp. 7 ◽

Cited By ~ 4

Author(s):

Abhijit Chandra ◽

Ashok Kumar ◽

M Noushif ◽

Nitish Gupta ◽

Vijay Kumar ◽

...

Keyword(s):

Pudendal Nerve ◽

Cadaveric Study ◽

Nerve Anastomosis

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Incorporation of Cholesterol into Peripheral Nerve Myelin

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100094930 ◽

1972 ◽

Vol 30 ◽

pp. 334-335

Author(s):

Frank A. Rawlins

Keyword(s):

Electron Microscope ◽

Sciatic Nerve ◽

Electron Microscope Autoradiography ◽

Myelin Sheaths ◽

Microscope Autoradiography ◽

Grain Distribution ◽

Sciatic Nerves ◽

Autoradiographic Analysis ◽

Old Mice ◽

Short Times

Several speculations exist as to the site of incorporation of preformed molecules into myelin. The possibility that an autoradiographic analysis of cholesterol-1,2-H3 incorporation at very short times after injection might shed some light in the solution of that problem led to the present experiment.Cholesterol-1,2-H3 was injected intraperitoneally into 24 tenday old mice. The animals were then sacrificed at 10,20,30,40,60,90,120 and 180 min after the injection and the sciatic nerves were processed for electron microscope autoradiography. To analyze the grain distribution in the autoradiograms of cross and longitudinal sections from each sciatic nerve myelin sheaths were subdivided into three compartments named: outer 1/3, middle 1/3 and inner 1/3 compartments.It was found that twenty min. after the injection of cholesterol -1.2-H3 (Figs. 1 and 2), 55% of the total number of grains (t.n.g) found in myelin were within the outer 1/3 compartment, 9% were within the middle 1/3 and 36% within the inner 1/3 compartment

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Anatomical feasibility of peripheral nerve transfer to reestablish external anal sphincter control – cadaveric study

Surgical and Radiologic Anatomy ◽

10.1007/s00276-020-02635-z ◽

2021 ◽

Author(s):

Andrea Povedano ◽

Rosana Siqueira Brown ◽

Daniel A. N. Barbosa ◽

Rossano Kepler Alvim Fiorelli ◽

Fernando Guedes

Keyword(s):

Peripheral Nerve ◽

Anal Sphincter ◽

External Anal Sphincter ◽

Nerve Transfer ◽

Cadaveric Study

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Prevention of painful neuromas by oblique transection of peripheral nerves

Journal of Neurosurgery ◽

10.3171/jns.2006.104.2.285 ◽

2006 ◽

Vol 104 (2) ◽

pp. 285-289 ◽

Cited By ~ 18

Author(s):

Wieslaw Marcol ◽

Katarzyna Kotulska ◽

Magdalena Larysz-Brysz ◽

Grazyna Bierzyñska-Macyszyn ◽

Pawel Wlaszczuk ◽

...

Keyword(s):

Neuropathic Pain ◽

Sciatic Nerve ◽

Peripheral Nerves ◽

Traditional Method ◽

Healing Process ◽

Nerve Transection ◽

Proximal Stump ◽

Sciatic Nerves ◽

Neuroma Formation

Object Neuroma formation often occurs at the proximal stump of the transected nerve, complicating the healing process after gap injuries or nerve biopsies. Most such neuromas cause therapy-resistant neuropathic pain. The purpose of this study was to determine whether oblique transection of the proximal stump of the sciatic nerve can prevent neuroma formation. Methods The sciatic nerves of 10 rats were transected unilaterally at an angle of 30°, and the peripheral segments of the nerves were removed. In 10 control animals the sciatic nerves were transected at a perpendicular angle. Twenty weeks after surgery the nerves were reexposed and collected. The presence of neuromas was determined by two board-certified pathologists on the basis of histopathological evaluations. Conclusions The oblique transection of peripheral nerves, contrary to perpendicularly transected nerves, is rarely followed by classic neuroma development. Moreover, neuropathic pain is significantly reduced compared with that following the traditional method of nerve transection.

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Anal sphincter reconstruction with a pudendal nerve anastomosis following abdominoperineal resection

Diseases of the Colon & Rectum ◽

10.1007/bf02070719 ◽

1997 ◽

Vol 40 (12) ◽

pp. 1497-1503 ◽

Cited By ~ 17

Author(s):

Tomoyuki Sato ◽

Fumio Konishi ◽

Kyotaro Kanazawa

Keyword(s):

Anal Sphincter ◽

Abdominoperineal Resection ◽

Pudendal Nerve ◽

Sphincter Reconstruction ◽

Nerve Anastomosis ◽

Anal Sphincter Reconstruction

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Distal nerve transfer from the median nerve lumbrical fibers to the distal ulnar nerve motor branches in the palm: An anatomical cadaveric study

Microsurgery ◽

10.1002/micr.30402 ◽

2018 ◽

Vol 39 (5) ◽

pp. 434-440

Author(s):

Michele R. Colonna ◽

Davide Pino ◽

Bruno Battiston ◽

Francesco Stagno d'Alcontres ◽

Konstantinos Natsis ◽

...

Keyword(s):

Median Nerve ◽

Ulnar Nerve ◽

Nerve Transfer ◽

Cadaveric Study ◽

Distal Nerve

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The dynamic changes of main cell types in the microenvironment of sciatic nerves following sciatic nerve injury and the influence of let-7 on their distribution

RSC Advances ◽

10.1039/c8ra08298g ◽

2018 ◽

Vol 8 (72) ◽

pp. 41181-41191 ◽

Cited By ~ 4

Author(s):

Tianmei Qian ◽

Pan Wang ◽

Qianqian Chen ◽

Sheng Yi ◽

Qianyan Liu ◽

...

Keyword(s):

Sciatic Nerve ◽

Peripheral Nerve ◽

Schwann Cells ◽

Nerve Injury ◽

Cell Types ◽

Sciatic Nerve Injury ◽

Dynamic Changes ◽

Main Cell ◽

Sciatic Nerves

Schwann cells (SCs), fibroblasts and macrophages are the main cells in the peripheral nerve stumps.

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THE EXCRETION OF CARBON DIOXIDE BY FROG NERVE

The Journal of General Physiology ◽

10.1085/jgp.8.2.21 ◽

1925 ◽

Vol 8 (2) ◽

pp. 21-31 ◽

Cited By ~ 6

Author(s):

G. H. Parker

Keyword(s):

Carbon Dioxide ◽

Sciatic Nerve ◽

Connective Tissue ◽

Nervous Tissue ◽

Average Rate ◽

Boiling Water ◽

Co2 Production ◽

Co2 Output ◽

Sciatic Nerves ◽

Low Rate

1. Quiescent sciatic nerve of the frog discharges CO2 at the average rate of 0.00876 mg. CO2 per gram of nerve per minute. 2. Sciatic nerve steeped one minute in boiling water discharges CO2 at first at a low rate and after an hour and a half not at all. 3. Degenerated sciatic nerve discharges CO2 at a slightly higher rate than normal living nerve does. 4. Connective tissue from the frog discharges CO2 at an average rate of 0.0097 mg. per gram of tissue per minute. 5. Assuming that a nerve is composed of from one-half to one-quarter connective tissue the CO2 output from its strictly nervous components is estimated to be at a rate of 0.008 mg. CO2 per gram of nerve per minute. 6. Stimulated sciatic nerve increases the rate of its CO2 output over quiescent nerve by about 14 per cent. When this number is corrected for strictly nervous tissue the rate is about 16 per cent. 7. The increased rate of CO2 production noted on stimulation in normal sciatic nerves was not observed when they were boiled, blocked, or degenerated. It was also not observed with stimulated strands of connective tissue.

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